Tilozīna fosfāta premikss

tilozīna fosfāts

Pharmacodynamics Tylosin is a macrolide antibiotic, which inhibits bacterial protein synthesis by blocking peptide transfer and mRNA displacement through reversible binding with 50S subunit of bacterial ribosome. This effect is basically limited to rapidly dividing bacteria and mycoplasmas, belonging to the growth period of fast acting bacteriostatic agents. This product is mainly effective against gram-positive bacteria and mycoplasma, with weak effect on bacteria and strong effect on mycoplasma. Sensitive gram-positive bacteria include Staphylococcus aureus (including penicillin resistant Staphylococcus aureus), pneumococcus, streptococcus, Bacillus anthracis, Listeria, Clostridium putrescence, Clostridium emphysema, etc. Sensitive bacteria can be resistant to tylosin, and Staphylococcus aureus has some cross resistance to tylosin and erythromycin.
Pharmacokinetics: Tylosin can be absorbed from gastrointestinal tract after oral administration. The peak concentration of blood drug can be reached 1 hour after oral administration in pigs. Tylosin phosphate is less absorbed. The concentration of tylosin in milk is about 20% of the serum concentration in the same period. Tylosin is excreted in its original form through urine and bile.

(1) Due to the same target, it should not be used at the same time as other macrolides and linecolines.
(2) And β- The combination of lactam showed antagonistic effect.

 Macrolide antibiotics. It is mainly used to prevent and treat diseases caused by mycoplasma infection in pigs and chickens, and also used to treat necrotizing enteritis caused by Clostridium perfringens in chickens.

Calculated by this product. Mixed feeding: 100~1000g per 1000kg of feed for pigs; Chicken 40-500g.

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