Colistin Sulfate Soluble Hmoov
Mucin
Cov khoom no yog dawb los yog yuav luag dawb hmoov.
Pharmacodynamics Myxin yog ib hom tshuaj tua kab mob polypeptide, uas yog ib hom alkaline cationic surfactant. Los ntawm kev sib cuam tshuam nrog phospholipids hauv cov kab mob hauv cov kab mob hauv cov kab mob, nws nkag mus rau hauv cov kab mob hauv cov kab mob hauv cov kab mob, rhuav tshem nws cov qauv, thiab tom qab ntawd ua rau muaj kev hloov pauv hauv daim nyias nyias permeability, ua rau cov kab mob tuag thiab cov kab mob bactericidal.
Cov khoom no muaj txiaj ntsig zoo rau cov kab mob aerobic, Escherichia coli, haemophilus, Klebsiella, Pasteurella, Pseudomonas aeruginosa.
Cov kab mob Gram tsis zoo xws li cov kab mob, salmonella thiab shigella muaj cov tshuaj tua kab mob muaj zog. Gram positive bacilli.Ntau zaus insensitive. Muaj kev ua tiav hla kev tiv thaiv nrog polymyxin B, tab sis tsis muaj kev tiv thaiv hla nrog lwm cov tshuaj tua kab mob.
Pharmacokinetics: Kev tswj hwm qhov ncauj tsis yooj yim nqus cov tshuaj, tab sis kev tswj hwm tsis yog plab hnyuv tau nqus nws sai. Cov tshuaj nkag mus rau hauv lub cev tuaj yeem ua tau sai.Nws tuaj yeem nkag mus rau hauv lub plawv, ntsws, siab, lub raum thiab cov leeg pob txha sai, tab sis nws tsis yooj yim rau nkag mus rau hauv lub hlwb, qaum qaum, hauv siab, sib koom ua ke kab noj hniav thiab hnov qab.
Mob foci. Nws yog tsuas yog excreted los ntawm lub raum.
(1) Ua ke nrog cov leeg nqaij so thiab cov neuromuscular blockers xws li aminoglycosides tuaj yeem ua rau cov leeg tsis muaj zog thiab apnea.
(2) Nws muaj kev sib koom ua ke nrog tus neeg saib xyuas chelating (EDTA) thiab cationic cleaner ntawm Pseudomonas aeruginosa, thiab feem ntau siv ua ke rau kev kho mob hauv zos.
Peptide tshuaj tua kab mob. Nws yog tsuas yog siv los kho cov kab mob hauv plab los ntawm kab mob gram-negative.
Muab xam los ntawm cov khoom no. Mixed haus: 0.4 ~ 2g rau npua thiab 0.2 ~ 0.6g rau nqaij qaib ib 1L dej; Kev pub mis sib xyaw: 0.4 ~ 0.8g ib 1kg pub rau npua.
Tsis muaj kev phiv tshwm sim thaum siv raws li kev siv thiab ntau npaum li cas.
(1) Cov qaib tso qe rau tib neeg noj yuav tsum tsis txhob siv thaum lub sij hawm tso.
(2) Kev siv tsis tu ncua yuav tsum tsis pub dhau ib lub lis piam.
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