Levamisole 1000mg Bolus

Levamisole yog nqus los ntawm lub plab tom qab noj qhov ncauj thiab los ntawm daim tawv nqaij tom qab daim ntawv thov dermal, txawm hais tias bioavailabilities kuj sib txawv. Nws raug tshaj tawm thoob plaws lub cev. Levamisole feem ntau metabolized nrog tsawg dua 6% tso tawm tsis hloov pauv hauv cov zis. Plasma tshem tawm ib nrab-lub neej tau txiav txim siab rau ntau hom tsiaj tsiaj: nyuj 4-6 teev; dev 1.8-4 teev; thiab Swine 3.5-6.8 teev. Cov metabolites tau tawm hauv ob qho tib si hauv cov zis (feem ntau) thiab quav.

Levamisole yog qhia rau kev kho mob ntawm ntau nematodes nyob rau hauv nyuj, yaj & tshis, swine, nqaij qaib. Hauv cov yaj thiab nyuj, levamisole muaj qhov ua tau zoo tiv thaiv cov kab mob abomasal nematodes, plab hnyuv nematodes (tsis tshwj xeeb zoo tiv thaiv Strongyloides spp.), cov plab hnyuv loj (tsis yog Trichuris spp.), thiab cov kab mob ntsws. Cov neeg laus cov ntaub ntawv uas feem ntau yog them los ntawm levamisole, xws li: Haemonchus spp., Trichostrongylus spp., Osteragia spp., Cooperia spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., Chabertia spp., thiab Dvaic purocus. Levamisole tsis tshua muaj txiaj ntsig tiv thaiv cov kab mob tsis paub qab hau ntawm cov kab mob no thiab feem ntau tsis muaj txiaj ntsig hauv cov nyuj (tab sis tsis yog yaj) tawm tsam cov ntaub ntawv larval raug ntes.

Hauv swine, levamisole yog qhia rau kev kho mob ntawm Ascaris suum, Oesophagostomum spp., Strongyloides, Stephanurus, thiab Metastrongylus.

Levamisole tau siv rau hauv cov dev ua microfilaricide los kho Dirofilaria immitis kab mob.

Levamisole yog contraindicated nyob rau hauv lactating tsiaj. Nws yuav tsum tau siv ceev faj, yog tias tag nrho, hauv cov tsiaj uas muaj mob hnyav, lossis muaj lub raum tsis zoo lossis mob siab. Siv ceev faj lossis, zoo dua, ncua kev siv cov nyuj uas ntxhov siab vim txhaj tshuaj tiv thaiv, dehorning lossis castration.

Tsis muaj ntaub ntawv hais txog kev nyab xeeb ntawm cov tshuaj no hauv cov tsiaj cev xeeb tub. Txawm hais tias levamisole suav hais tias muaj kev nyab xeeb rau cov tsiaj loj uas cev xeeb tub, tsuas yog siv yog tias cov txiaj ntsig muaj txiaj ntsig tshaj qhov txaus ntshai.

Cov teebmeem tsis zoo uas tuaj yeem pom hauv nyuj tuaj yeem suav nrog muzzle-foaming lossis hypersalivation, zoo siab lossis tshee, di ncauj-licking thiab lub taub hau co. Cov teebmeem no feem ntau tau sau tseg nrog ntau dua cov koob tshuaj pom zoo lossis yog tias levamisole tau siv ua ke nrog organophosphates. Cov tsos mob feem ntau yuav qis hauv 2 teev. Thaum txhaj rau hauv nyuj, o tuaj yeem tshwm sim ntawm qhov chaw txhaj tshuaj. Qhov no feem ntau yuav txo qis hauv 7-14 hnub, tab sis tej zaum yuav tsis pom zoo rau cov tsiaj uas ze rau kev tua.

 Hauv cov yaj, levamisole tuaj yeem ua rau muaj kev ntxhov siab nyob rau qee yam tsiaj tom qab noj. Hauv tshis, levamisole tuaj yeem ua rau muaj kev nyuaj siab, hyperesthesia thiab salivation.
 Hauv swine, levamisole tuaj yeem ua rau salivation lossis muzzle foaming. Swine kis tus kab mob ntsws tuaj yeem ua rau hnoos lossis ntuav.

 Cov teebmeem tsis zoo uas tuaj yeem pom hauv dev muaj xws li GI cuam tshuam (feem ntau ntuav, raws plab), neurotoxicity (panting, co, ntxhov siab lossis lwm yam kev hloov ntawm tus cwj pwm), agranulocytosis, dyspnea, pulmonary edema, tiv thaiv kab mob ntawm daim tawv nqaij eruptions (erythroedema, erythema multiforme, tshuaj lom neeg. epidermal necrolysis) thiab lethargy.

 Cov tsos mob tshwm sim hauv miv muaj xws li hypersalivation, excitement, mydriasis thiab ntuav.
 

Rau kev tswj qhov ncauj.

Cov koob tshuaj dav dav yog 5-7.5 mg Levamisole ib kg lub cev hnyav.

Yog xav paub ntxiv txog cov bolus, saib cov lus hauv qab no.

Bolus Dosage:

150mg 1 bolus rau 25 kg lub cev hnyav.

600 mg 1 bolus rau 100 kg lub cev hnyav.

1000mg 1 bolus rau 150kg lub cev hnyav.

Nyuj (nqaij & offal): 5 hnub.

Yaj (nqaij & offal): 5 hnub.

Tsis txhob siv rau hauv cov tsiaj uas tsim cov mis nyuj rau tib neeg noj.

Qhov pom zoo cia siab tshaj plaws yog 30 ℃.

Ceeb Toom: Khaws kom deb ntawm cov menyuam yaus.