Erythromycin Thiocyanate Soluble ntụ ntụ

Erythromycin

Ngwaahịa a dị ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ntụ ntụ.

Pharmacodynamics Erythromycin bụ ọgwụ nje macrolide. Mmetụta ngwaahịa a na nje bacteria gram-positive yiri penicillin, mana ụdị nje nje ya dị mbara karịa penicillin. Nje bacteria na-enwe mmetụta nke gram-positive gụnyere Staphylococcus aureus (gụnyere penicillin na-eguzogide Staphylococcus aureus), pneumococcus, streptococcus, anthrax, erysipelas suis, listeria, clostridium putrescens, clostridium anthracis, wdg. Sensitive gram-emccus influence, bacteria na-adịghị mma , wdg Na mgbakwunye, ọ nwekwara mmetụta dị mma na Campylobacter, Mycoplasma, Chlamydia, Rickettsia na Leptospira. A na-akwalite ọrụ antibacterial nke erythromycin thiocyanate na ngwọta alkaline. Mgbe pH mụbara site na 5.5 ruo 8.5, ọrụ antibacterial ji nwayọọ nwayọọ mụbaa. Pharmacokinetics Erythromycin base na stearate dị mfe imebi site na gastric acid mgbe ejiri ọnụ kwuo ya. Ụdị na usoro onunu ogwu nke nnu Erythromycin, acidity nke eriri afọ na nri dị n'ime afọ na-emetụta bioavailability ya. Naanị nkwadebe mkpuchi nke enteric nwere ike itinye uche nke ọma. Mgbe a gbasasịrị ya, a na-ekesa ya n'ụdị dị iche iche na mmiri ahụ, mana ọ naghị abanye n'ime mmiri cerebrospinal. Ọnụego njikọ protein plasma bụ. 73% ~ 81% obere akụkụ nke erythromycin bụ metabolized dị ka N-methyl erythromycin adịghị arụ ọrụ n'ime imeju, nke a na-apụkarị na bile prototype. Naanị 2% ~ 5% nke dose ka a na-ewepụ na mmamịrị prototype.

(1) Ngwaahịa a adabaghị maka ojiji n'otu oge macrolides na lincomamines ndị ọzọ n'ihi otu ebumnuche.

(2) Mgbe ejikọtara ya na B-lactam, ọ na-enwe mmetụta mgbochi.

(3) Ọ nwere ike igbochi usoro cytochrome oxidase, ma nwee ike igbochi metabolism ya mgbe ejiri ọgwụ ụfọdụ.

Ọgwụ nje macrolide. A na-eji ya agwọ ọrịa na-efe efe nke nje bacteria gram-positive na mycoplasma na ọkụkọ kpatara. Dị ka ọrịa staphylococcal, ọrịa streptococcal, ọrịa iku ume na-adịghị ala ala na rhinitis na-efe efe na ọkụkọ.

Ngwaahịa a gbakọrọ ya. Ihe ọṅụṅụ agwakọtara: 2.5g ọkụkọ kwa 1l mmiri. Enwere ike iji ya mgbe niile maka ụbọchị 3-5.

 Mgbe nchịkwa ọnụ gasịrị, ụmụ anụmanụ na-enwekarị nsogbu nke eriri afọ na-adabere na ya, dị ka afọ ọsịsa.

(1) A gaghị eji ọkụkọ na-akụ akwa maka oriri mmadụ n'oge ịtọgbọ.
(2) Ngwaahịa a ekwesịghị ikwekọ na ihe acidic.

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