Erythromycin Thiocyanate phofo e qhibilihang
Erythromycin
Sehlahisoa sena ke phofo e tšoeu kapa e batlang e le tšoeu.
Pharmacodynamics Erythromycin ke lithibela-mafu tsa macrolide. Phello ea sehlahisoa sena ho libaktheria tsa gram-positive e tšoana le penicillin, empa antibacterial spectrum ea eona e pharaletseng ho feta penicillin. Libaktheria tse utloang gram-positive li kenyelletsa Staphylococcus aureus (ho kenyeletsoa Staphylococcus aureus e hanyetsanang le penicillin), pneumococcus, streptococcus, anthrax, erysipelas suis, listeria, clostridium putrescens, clostridium anthracis, joalo-joalo. Pasteurella, joalo-joalo Ho phaella moo, e boetse e na le liphello tse ntle ho Campylobacter, Mycoplasma, Chlamydia, Rickettsia le Leptospira. Ts'ebetso ea antibacterial ea erythromycin thiocyanate ka tharollo ea alkaline e ile ea ntlafatsoa. Ha pH e eketseha ho tloha ho 5.5 ho isa ho 8.5, ts'ebetso ea antibacteria e ile ea eketseha butle-butle. Pharmacokinetics Erythromycin base le stearate li bonolo ho senyeha ka gastric acid ha e nkoa ka molomo. Mofuta le mofuta oa litekanyetso tsa letsoai la Erythromycin, acidity ea pampiri ea ka mpeng le lijo tse ka mpeng kaofela li ama bioavailability ea eona. Litokisetso tse koahetsoeng ke enteric feela li ka kenngoa hantle. Ka mor'a ho monya, e ajoa haholo ka har'a lisele tse fapaneng le maro a 'mele, empa ke ka seoelo e kenang cerebrospinal fluid. Sekhahla se tlamang protheine ea plasma ke. 73% ~ 81%. Karolo e nyane ea erythromycin e entsoe ka metabolized e le N-methyl erythromycin e sa sebetseng ka har'a sebete, e ntšoang haholo ho prototype bile. Ke 2% ~ 5% feela ea lethal dose e hlahisoang ka har'a moroto oa mohlala.
(1) Sehlahisoa sena ha sea lokela ho sebelisoa ka nako e le 'ngoe le li-macrolides tse ling le lincomamine ka lebaka la sepheo se tšoanang.
(2) Ha e kopantsoe le B-lactam, e na le phello e hanyetsanang.
(3) E ka thibela tsamaiso ea cytochrome oxidase, 'me e ka thibela metabolism ea eona ha e sebelisoa le lithethefatsi tse ling.
Li-antibiotics tsa macrolide. E sebelisoa ho phekola mafu a tšoaetsanoang a bakoang ke baktheria ea gram-positive le mycoplasma likhoho. Tse kang lefu la staphylococcal, lefu la streptococcal, lefu le sa foleng la ho hema le rhinitis e tšoaetsanoang likhoho.
E baloang ke sehlahisoa sena. Seno se tsoakiloeng: 2.5g ea khoho ka 1L ea metsi. E ka sebelisoa kamehla bakeng sa matsatsi a 3-5.
Kamora ho tsamaisoa ka molomo, hangata liphoofolo li na le mathata a amanang le mala a itšetlehileng ka tekanyo, joalo ka letšollo.
(1) Likhoho tse behelang mahe ho jeoa ke batho li ke ke tsa sebelisoa nakong ea ho behela.
(2) Sehlahisoa sena ha sea lokela ho lumellana le lintho tse nang le asiti.
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