Erythromycin Thiocyanate ufa wosungunuka

Erythromycin

Mankhwalawa ndi oyera kapena pafupifupi ufa woyera.

Pharmacodynamics Erythromycin ndi macrolide antibiotic. Zotsatira za mankhwalawa pa mabakiteriya a gram-positive ndi ofanana ndi penicillin, koma antibacterial spectrum yake ndi yotakata kuposa penicillin. Mabakiteriya omwe ali ndi gram-positive amaphatikizapo Staphylococcus aureus (kuphatikiza Staphylococcus aureus yolimbana ndi penicillin), pneumococcus, streptococcus, anthrax, erysipelas suis, listeria, clostridium putrescens, clostridium anthracis, ndi zina zotero. Pasteurella, etc. Komanso, alinso zotsatira zabwino Campylobacter, Mycoplasma, mauka, Rickettsia ndi Leptospira. Ntchito ya antibacterial ya erythromycin thiocyanate mu njira ya alkaline idakulitsidwa. Pamene pH idakwera kuchokera ku 5.5 mpaka 8.5, ntchito ya antibacterial idakula pang'onopang'ono. Pharmacokinetics Erythromycin base ndi stearate ndizosavuta kunyozedwa ndi chapamimba asidi akamwedwa pakamwa. Mtundu ndi mlingo wa mchere wa Erythromycin, acidity wa m'mimba ndi chakudya cha m'mimba zimakhudza bioavailability yake. Zokonzekera zokhala ndi enteric zokha zimatha kuyamwa bwino. Pambuyo mayamwidwe, ambiri anagawira zosiyanasiyana zimakhala ndi madzimadzi amthupi, koma kawirikawiri amalowa mu cerebrospinal madzimadzi. Mlingo womanga mapuloteni a plasma ndi. 73% ~ 81%. Kagawo kakang'ono ka erythromycin amapangidwa ngati inactive N-methyl erythromycin mu chiwindi, amene makamaka excreted mu prototype bile. 2% ~ 5% yokha ya mlingo imachotsedwa mumkodzo wofanana.

(1) Izi sizoyenera kugwiritsidwa ntchito nthawi yomweyo monga ma macrolides ena ndi lincomamines chifukwa cha chandamale chomwechi.

(2) Ikaphatikizidwa ndi B-lactam, imakhala ndi zotsatira zotsutsana.

(3) Ikhoza kulepheretsa dongosolo la cytochrome oxidase, ndipo ikhoza kulepheretsa kagayidwe kake kakagwiritsidwa ntchito ndi mankhwala ena.

Maantibayotiki a Macrolide. Amagwiritsidwa ntchito pochiza matenda opatsirana omwe amayamba chifukwa cha mabakiteriya a gram-positive ndi mycoplasma mu nkhuku. Monga staphylococcal matenda, streptococcal matenda, aakulu kupuma matenda ndi matenda rhinitis mu nkhuku.

Kuwerengeredwa ndi mankhwalawa. Chakumwa chosakaniza: 2.5g nkhuku pa 1L madzi. Itha kugwiritsidwa ntchito mosalekeza kwa masiku 3-5.

 Pambuyo makonzedwe m`kamwa, nyama zambiri mlingo amadalira matenda a m`mimba, monga kutsekula m`mimba.

(1) Nkhuku zoikira mazira kuti anthu adye siziyenera kugwiritsidwa ntchito panthawi yoikira.
(2) Izi siziyenera kugwirizana ndi zinthu za acidic.

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