Paura Florfenicol
florfenicol
He ma, he paura tata ranei tenei hua.
Pharmacodynamics: no roto te florfenicol ki nga paturopi whanui-a-whanui o nga waipiro amide me nga matū bacteriostatic. Ka whai waahi ma te whakakotahi me te ribosom 50S subunit ki te aukati i te whakahiato o te pūmua huakita. He kaha te mahi antibacterial ki nga momo huakita karamu-pai me te karamu-kino. Ko te Pasteurella haemolytica, ko te Pasteurella multocida me te Actinobacillus pleuropneumoniae i tino aro ki te florfenicol. In vitro, he rite, he kaha ake ranei te mahi antibacterial o te florfenicol ki te maha o nga microorganisms i tera o te thiamphenicol. Ko etahi huakita e atete ana ki nga waipiro amida na te acetylation, penei i te Escherichia coli, Klebsiella pneumoniae, kei te tairongo tonu ki te florfenicol.
Ka whakamahia te nuinga mo nga mate huakita o nga poaka, heihei me nga ika i puta mai i nga huakita tairongo, penei i te Pasteurella haemolytica, te Pasteurella multocida me nga mate manawa o te kau me te poaka na te Actinobacillus pleuropneumoniae. Salmonella Typhoid me te paratyphoid fever, heihei kolera, heihei pullorum, mate Escherichia coli, etc; Septicemia huakita ika, enteritis, kiri whero na Pasteurella, Vibrio, Staphylococcus aureus, Hydromonas, huakita enteritis, aha atu Te mate, etc.
Pharmacokinetics Flufenicol Ka taea te ngongo tere i muri i te whakahaere a-waha, a ka tae atu te kukū haumanu i roto i te toto mo te 1 haora i muri mai, ka taea te tae te kukū plasma teitei i roto i te 1~3 haora. Ko te koiora kei runga ake i te 80%. Ka tohatohahia a Florfenicol i roto i nga kararehe me te taea Na roto i te arai toto-roro. Ko te nuinga ka tukuna mai i te mimi i roto i te ahua taketake, me te iti o te nui ka tukuna ki te tai.
(1) He rite te whainga mahi a te Macrolides me te lincomamines ki tenei hua, ka herea enei e rua ki te 50S subunit o te ribosome huakita, a ka taea te whakaputa antagonism ina whakamahia tahi.
(2) Ka whakahē pea i te mahi huakita o te penicillin me te aminoglycoside, engari kaore ano kia whakamatauhia ki nga kararehe.
Paturopi waipiro Amide. Mo nga mate o Pasteurella me Escherichia coli.
Ka tatauhia e tenei hua. Te whakahaere a-waha: 0.1-0.15g mo nga poaka me nga heihei mo te 1kg te taimaha o te tinana, e rua nga wa ia ra, mo nga ra 3-5 karapīpiti: 50-75mg mo te ika, kotahi i te ra, mo nga ra 3-5.
Ko tenei hua he awenga immunosuppressive ina whakamahia ki te inenga teitei ake i te inenga kua tohua.
(1) Ko nga heihei e whakatakoto hua ana hei kai ma te tangata, kaua e whakamahia i roto i te waa whakapanga.
(2) Kia tupato te whakamahi heihei whakatipu. He embryotoxicity, a me whakamahi ma te tupato mo nga kararehe i te wa e hapu ana me te whakawhanau.
(3) Karehia te whakamahi i te kararehe i te wa o te kano kano kano, i te wa e tino ngoikore ana te mahi aukati.
(4) He mea tika ki te whakaiti i te inenga, ki te whakaroa ranei i te waahi o te whakahaere mo nga kararehe he ngoikore te renal.
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