ʻO ka pauda Florfenicol

 florfenicol

He keʻokeʻo a aneane keʻokeʻo kēia huahana.

Pharmacodynamics: Aia ka florfenicol i nā lāʻau lapaʻau ākea ākea o nā amide alcohols a me nā mea bacteriostatic. He hana ia ma ka hui pū ʻana me ribosomal 50S subunit e kāohi i ka synthesis o ka protein bacterial. Loaʻa iā ia ka hana antibacterial ikaika e kūʻē i nā ʻano bacteria gram-positive a me gram-negative. ʻO Pasteurella haemolytica, Pasteurella multocida a me Actinobacillus pleuropneumoniae ua maʻalahi loa i ka florfenicol. I loko o ka vitro, ua like a ʻoi aku ka ikaika o ka hana antibacterial o florfenicol e kūʻē i nā microorganism he nui ma mua o ka thiamphenicol. ʻO kekahi mau maʻi bacteria e kūʻē i ka amide alcohols ma muli o ka acetylation, e like me Escherichia coli, Klebsiella pneumoniae, hiki ke maʻalahi i ka florfenicol.

Hoʻohana nui ʻia ia no nā maʻi bacterial o nā puaʻa, nā moa a me nā iʻa i hoʻokumu ʻia e ka maʻi bacteria sensitive, e like me Pasteurella haemolytica, Pasteurella multocida a me nā maʻi hanu o nā pipi a me nā puaʻa i hana ʻia e Actinobacillus pleuropneumoniae. Salmonella Typhoid a me ka paratyphoid fever, moa kolera, moa pullorum, Escherichia coli maʻi, etc; Iʻa bacterial septicemia, enteritis, ʻili ʻulaʻula i hana ʻia e Pasteurella, Vibrio, Staphylococcus aureus, Hydromonas, enteritis bacteria, etc.

ʻO ka Pharmacokinetics Flufenicol hiki ke hoʻopili koke ʻia ma hope o ka hoʻokele waha, a hiki ke loaʻa ka ʻike therapeutic i loko o ke koko ma kahi o 1 hola ma hope, a hiki ke hōʻea i ka pae kiʻekiʻe o ka plasma i loko o 1 ~ 3 mau hola. Aia ka bioavailability ma luna o 80%. Hoʻolaha nui ʻia ʻo Florfenicol i nā holoholona a hiki Ma o ka pale koko-lolo. Hoʻokuʻu nui ʻia mai ka mimi ma ke ʻano kumu, a hoʻokuʻu ʻia kahi mea liʻiliʻi me nā feces.

(1) Loaʻa i nā Macrolides a me nā lincomamines ka pahuhopu hana like me kēia huahana, ua hoʻopaʻa ʻia ia mau mea ʻelua i 50S subunit o bacterial ribosome, a hiki ke hana i ka antagonism like ke hoʻohana pū ʻia.
(2) Hiki ke kū'ē i ka hana bactericidal o penicillin a i ʻole aminoglycoside lāʻau, akā ʻaʻole i hōʻoia ʻia i nā holoholona.

ʻO nā lāʻau lapaʻau ʻona Amide. No nā maʻi Pasteurella a me Escherichia coli.

Ua helu ʻia e kēia huahana. Hoʻoponopono waha: 0.1-0.15g no nā puaʻa a me nā moa no ka 1kg kaumaha o ke kino, ʻelua i ka lā, no 3-5 mau lā: 50-75mg no ka iʻa, hoʻokahi manawa i ka lā, no 3-5 mau lā.

Loaʻa i kēia huahana kekahi hopena immunosuppressive ke hoʻohana ʻia ma kahi ʻano kiʻekiʻe ma mua o ke ʻano i ʻōlelo ʻia.

(1) ʻAʻole e hoʻohana ʻia nā moa e hoʻomoe ana i nā hua no ka ʻai kanaka i ka wā hoʻomoe.
(2) Pono e hoʻohana ʻia nā moa hānai me ka akahele. Loaʻa iā ia ka embryotoxicity, a pono e hoʻohana me ka akahele no nā holoholona i ka wā hāpai a me ka lactation.
(3) ʻAʻole ʻae ʻia ka hoʻohana ʻana i ka holoholona i ka wā o ka lāʻau lapaʻau a i ʻole i ka wā i hoʻopilikia nui ʻia ka hana o ka immune.
(4) Pono e hōʻemi i ka dosage a i ʻole e hoʻolōʻihi i ka wā o ka lawelawe ʻana no nā holoholona me ka lawa ʻole o ka renal.

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