Florfenicol ufa

 florfenicol

Mankhwalawa ndi oyera kapena pafupifupi ufa woyera.

Pharmacodynamics: florfenicol ndi ya maantibayotiki osiyanasiyana a amide alcohols ndi bacteriostatic agents. Zimagwira ntchito pophatikiza ndi ribosomal 50S subunit kuti ziletse kaphatikizidwe ka mapuloteni a bakiteriya. Lili ndi mphamvu yolimbana ndi mabakiteriya osiyanasiyana a gram-positive ndi gram-negative. Pasteurella haemolytica, Pasteurella multocida ndi Actinobacillus pleuropneumoniae anali okhudzidwa kwambiri ndi florfenicol. In vitro, antibacterial zochita za florfenicol motsutsana ndi tizilombo tambiri ndizofanana kapena zamphamvu kuposa za thiamphenicol. Mabakiteriya ena osamva mowa wa amide chifukwa cha acetylation, monga Escherichia coli, Klebsiella pneumoniae, angakhalebe okhudzidwa ndi florfenicol.

Amagwiritsidwa ntchito kwambiri pa matenda a bakiteriya a nkhumba, nkhuku ndi nsomba zomwe zimayambitsidwa ndi mabakiteriya okhudzidwa, monga Pasteurella haemolytica, Pasteurella multocida ndi matenda opuma a ng'ombe ndi nkhumba chifukwa cha Actinobacillus pleuropneumoniae. Salmonella Typhoid ndi paratyphoid fever, kolera ya nkhuku, nkhuku pullorum, Escherichia coli matenda, etc; Nsomba bakiteriya septicemia, enteritis, wofiira khungu chifukwa Pasteurella, Vibrio, Staphylococcus aureus, Hydromonas, enteritis mabakiteriya, etc Matenda, etc.

Pharmacokinetics Flufenicol imatha kuyamwa mwachangu pambuyo pakamwa, ndipo ndende yochizira imatha kufikika m'magazi pafupifupi ola limodzi, ndipo ndende yayikulu ya plasma imatha kufikira mkati mwa maola 1-3. The bioavailability ndi pamwamba 80%. Florfenicol imagawidwa kwambiri mu nyama ndipo imatha Kudzera mu chotchinga chamagazi muubongo. Imatulutsidwa makamaka mumkodzo mu mawonekedwe oyambirira, ndipo pang'ono imatulutsidwa ndi ndowe.

(1) Macrolides ndi lincomamines ali ndi chandamale chofanana ndi mankhwalawa, onse omwe amamangidwa ndi 50S subunit ya bakiteriya ribosome, ndipo amatha kubweretsa kusagwirizana akagwiritsidwa ntchito limodzi.
(2) Ikhoza kusokoneza ntchito ya bactericidal ya penicillin kapena aminoglycoside mankhwala, koma sizinatsimikizidwe mu zinyama.

Amide mowa maantibayotiki. Kwa matenda a Pasteurella ndi Escherichia coli.

Kuwerengeredwa ndi mankhwalawa. Oral makonzedwe: 0.1-0.15g nkhumba ndi nkhuku pa 1kg thupi, kawiri pa tsiku, kwa 3-5 motsatizana masiku: 50-75mg nsomba, kamodzi patsiku, kwa 3-5 masiku zotsatizana.

Mankhwalawa ali ndi mphamvu ya immunosuppressive akagwiritsidwa ntchito pa mlingo wapamwamba kuposa mlingo woyenera.

(1) Nkhuku zoikira mazira kuti anthu adye siziyenera kugwiritsidwa ntchito panthawi yoikira.
(2) Nkhuku zoweta zizigwiritsidwa ntchito mosamala. Ili ndi embryotoxicity, ndipo iyenera kugwiritsidwa ntchito mosamala pa ziweto pa nthawi ya mimba ndi lactation.
(3) Ndi zoletsedwa kugwiritsa ntchito chiweto panthawi ya katemera kapena pamene chitetezo cha mthupi chimalephereka kwambiri.
(4) M'pofunika kuchepetsa mlingo kapena kutalikitsa nthawi ya makonzedwe kwa nyama ndi aimpso insufficiency.

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