Florfenicol hmoov

 florfenicol

Cov khoom no yog dawb los yog yuav luag dawb hmoov.

Pharmacodynamics: florfenicol belongs rau broad-spectrum tshuaj tua kab mob ntawm amide alcohols thiab bacteriostatic agents. Nws ua lub luag haujlwm los ntawm kev sib txuas nrog ribosomal 50S subunit los tiv thaiv kev sib txuas ntawm cov kab mob protein. Nws muaj zog tiv thaiv kab mob tiv thaiv ntau yam kab mob gram-positive thiab gram-negative kab mob. Pasteurella haemolytica, Pasteurella multocida thiab Actinobacillus pleuropneumoniae tau rhiab heev rau florfenicol. Hauv vitro, cov tshuaj tua kab mob ntawm florfenicol tiv thaiv ntau cov kab mob zoo sib xws lossis muaj zog dua li ntawm thiamphenicol. Qee cov kab mob resistant rau amide alcohols vim acetylation, xws li Escherichia coli, Klebsiella pneumoniae, tej zaum tseem yuav rhiab heev rau florfenicol.

Nws yog tsuas yog siv rau cov kab mob ntawm cov npua, qaib thiab ntses los ntawm cov kab mob rhiab heev, xws li Pasteurella haemolytica, Pasteurella multocida thiab kab mob ua pa ntawm nyuj thiab npua los ntawm Actinobacillus pleuropneumoniae. Salmonella Typhoid thiab paratyphoid fever, qaib cholera, nqaij qaib pullorum, Escherichia coli kab mob, thiab lwm yam; Ntses kab mob septicemia, enteritis, daim tawv nqaij liab tshwm sim los ntawm Pasteurella, Vibrio, Staphylococcus aureus, Hydromonas, enteritis kab mob, thiab lwm yam mob, thiab lwm yam.

Pharmacokinetics Flufenicol tuaj yeem nqus tau sai sai tom qab kev tswj hwm qhov ncauj, thiab cov tshuaj kho mob tuaj yeem ncav cuag hauv cov ntshav li 1 teev tom qab, thiab qhov siab tshaj plaws plasma concentration tuaj yeem ncav cuag li 1 ~ 3 teev. Lub bioavailability yog siab dua 80%. Florfenicol yog dav faib nyob rau hauv cov tsiaj thiab muaj peev xwm los ntawm cov ntshav-hlwb barrier. Nws yog tsuas yog tso tawm los ntawm cov zis nyob rau hauv thawj daim ntawv, thiab ib tug me me npaum li cas yog tawm nrog quav.

(1) Macrolides thiab lincomamines muaj tib lub hom phiaj ua haujlwm raws li cov khoom no, ob qho tib si yog khi rau 50S subunit ntawm cov kab mob ribosome, thiab tuaj yeem tsim kev sib nrig sib antagonism thaum siv ua ke.
(2) Nws tuaj yeem tiv thaiv cov kab mob bactericidal ntawm penicillin lossis aminoglycoside tshuaj, tab sis nws tsis tau muaj pov thawj hauv cov tsiaj.

Amide cawv tshuaj tua kab mob. Rau cov kab mob Pasteurella thiab Escherichia coli.

Muab xam los ntawm cov khoom no. Kev tswj qhov ncauj: 0.1-0.15g rau npua thiab qaib ib 1kg lub cev qhov hnyav, ob zaug ib hnub, rau 3-5 hnub sib law liag: 50-75mg rau ntses, ib zaug ib hnub, rau 3-5 hnub sib law liag.

Cov khoom no muaj qee yam kev tiv thaiv kab mob thaum siv ntawm qhov ntau npaum li qhov pom zoo.

(1) Cov qaib tso qe rau tib neeg noj yuav tsum tsis txhob siv thaum lub sij hawm tso.
(2) Kev yug qaib yuav tsum tau siv ceev faj. Nws muaj embryotoxicity, thiab yuav tsum tau siv nrog ceev faj rau cov tsiaj txhu thaum cev xeeb tub thiab lactation.
(3) Nws yog txwv tsis pub siv tus tsiaj thaum lub sijhawm txhaj tshuaj tiv thaiv lossis thaum lub cev tsis muaj zog.
(4) Nws yog ib qho tsim nyog los txo qhov ntau npaum li cas los yog ncua lub sijhawm ntawm kev tswj hwm rau cov tsiaj uas muaj lub raum tsis txaus.

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