Florfenicol Powder

 florfenicol

Ichi chigadzirwa chichena kana chinenge chena poda.

Pharmacodynamics: florfenicol ndeye yakafara-spectrum antibiotics yeamide alcohols uye bacteriostatic agents. Inoita basa nekubatanidza ne ribosomal 50S subunit kuvharidzira kuumbwa kweprotein yebhakitiriya. Iine simba rinorwisa mabhakitiriya rinopikisa zvakasiyana-siyana zve gram-positive uye gram-negative mabhakitiriya. Pasteurella haemolytica, Pasteurella multocida uye Actinobacillus pleuropneumoniae vainzwa zvakanyanya neflorfenicol. In vitro, iyo antibacterial chiitiko cheflorfenicol kurwisa tupukanana twakawanda yakafanana kana yakasimba kupfuura iyo yethiamphenicol. Mamwe mabhakitiriya anopokana neamide alcohols nekuda kweacetylation, senge Escherichia coli, Klebsiella pneumoniae, anogona kunge achiri kunzwa kune florfenicol.

Inonyanya kushandiswa kuzvirwere zvebhakitiriya zvenguruve, huku nehove zvinokonzerwa nehutachiona hwehutachiona, hwakadai sePasteurella haemolytica, Pasteurella multocida uye zvirwere zvekufema zvemombe nenguruve zvinokonzerwa neActinobacillus pleuropneumoniae. Salmonella Typhoid uye paratyphoid fever, chicken cholera, chicken pullorum, Escherichia coli chirwere, nezvimwewo; Hove bhakitiriya septicemia, enteritis, ganda dzvuku rinokonzerwa naPasteurella, Vibrio, Staphylococcus aureus, Hydromonas, enteritis bacteria, etc Kurwara, nezvimwe.

Pharmacokinetics Flufenicol inogona kutorwa nekukurumidza mushure mekutonga nemuromo, uye iyo yekurapa yekumisikidza inogona kusvika muropa inenge 1 awa gare gare, uye peak plasma concentration inogona kusvika mukati me1 ~ 3 maawa. Iyo bioavailability iri pamusoro pe80%. Florfenicol inoparadzirwa zvakanyanya mumhuka uye inogona Kuburikidza neropa-brain barriers. Inonyanya kubudiswa kubva muweti muchimiro chepakutanga, uye chiduku chiduku chinobudiswa netsvina.

(1) Macrolides uye lincomamines ane zvakafanana chiito chinangwa sechigadzirwa ichi, ese ari maviri akasungwa ku50S subunit yebhakitiriya ribosome, uye anogona kuburitsa kupokana kana akashandiswa pamwechete.
(2) Inogona kupikisa bactericidal chiitiko chepenicillin kana aminoglycoside mishonga, asi haina kuratidzwa mumhuka.

Amide doro remishonga inorwisa mabhakitiriya. Kune Pasteurella uye Escherichia coli zvirwere.

Yakaverengerwa nechigadzirwa ichi. Oral administration: 0.1-0.15g yenguruve nehuku pa1kg yehuremu hwemuviri, kaviri pazuva, kwemazuva 3-5 akatevedzana: 50-75mg yehove, kamwe chete pazuva, kwemazuva 3-5 akatevedzana.

Ichi chigadzirwa chine imwe immunosuppressive mhedzisiro kana ichishandiswa pachiyero chepamusoro pane chinokurudzirwa dosi.

(1) Huku dzinokandira mazai kuti dzidyiwe nevanhu hadzifanirwe kushandiswa panguva yekukandira.
(2) Kuuchika huku kunofanira kushandiswa nokungwarira. Iine embryotoxicity, uye inofanira kushandiswa nekuchenjerera kune zvipfuyo panguva yekuzvitakura uye lactation.
(3) Inorambidzwa kushandisa mhuka panguva yekudzivirira kana kana basa rekudzivirira zvirwere rakanyanyisa.
(4) Izvo zvinodikanwa kudzikisa dosage kana kurebesa nguva yekutonga kune mhuka dzine renal insufficiency.

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