Florfenicol foda

 florfenicol

Wannan samfurin fari ne ko kusan fari foda.

Pharmacodynamics: florfenicol nasa ne na maganin rigakafi da yawa na amide alcohols da wakilai na bacteriostatic. Yana taka rawa ta hanyar haɗawa da ribosomal 50S subunit don hana haɗin furotin na kwayan cuta. Yana da aikin kashe kwayoyin cuta mai ƙarfi akan ƙwayoyin cuta iri-iri na gram-tabbatacce da gram-korau. Pasteurella haemolytica, Pasteurella multocida da Actinobacillus pleuropneumoniae sun kasance masu kula da florfenicol sosai. A cikin vitro, aikin ƙwayoyin cuta na florfenicol akan ƙwayoyin cuta da yawa yana kama da na thiamphenicol. Wasu ƙwayoyin cuta masu jure wa alcohol na amide saboda acetylation, kamar Escherichia coli, Klebsiella pneumoniae, na iya har yanzu suna kula da florfenicol.

An fi amfani da shi don cututtukan ƙwayoyin cuta na aladu, kaji da kifi waɗanda ke haifar da ƙwayoyin cuta masu mahimmanci, irin su Pasteurella haemolytica, Pasteurella multocida da cututtukan numfashi na shanu da aladu waɗanda Actinobacillus pleuropneumoniae ke haifarwa. Salmonella Typhoid da paratyphoid zazzabi, kwalara kaji, kaza pullorum, Escherichia coli cuta, da dai sauransu; Kifi bakteriya septicemia, enteritis, ja fata wanda Pasteurella, Vibrio, Staphylococcus aureus, Hydromonas, enteritis kwayoyin cuta, da dai sauransu Cututtuka, da dai sauransu.

Pharmacokinetics Flufenicol za a iya tunawa da sauri bayan gudanar da baki, kuma ana iya kaiwa ga maida hankali a cikin jini kamar awa 1 bayan haka, kuma za'a iya kaiwa ga mafi girman ƙwayar plasma a cikin sa'o'i 1 ~ 3. Matsalolin bioavailability ya wuce 80%. Florfenicol yana yaduwa a cikin dabbobi kuma yana iya Ta hanyar shingen kwakwalwar jini. An fi fitar da shi daga fitsari a asali, kuma ana fitar da dan kadan da najasa.

(1) Macrolides da lincomamines suna da manufa iri ɗaya kamar wannan samfurin, dukansu biyun suna daure zuwa 50S subunit na ribosome na kwayan cuta, kuma suna iya haifar da gaba da juna idan aka yi amfani da su tare.
(2) Yana iya ƙin aikin ƙwayoyin cuta na penicillin ko magungunan aminoglycoside, amma ba a tabbatar da hakan a cikin dabbobi ba.

Amide barasa maganin rigakafi. Don cutar da Pasteurella da Escherichia coli.

Wannan samfurin ya ƙididdige shi. Gudanar da baka: 0.1-0.15g na alade da kaji da nauyin 1kg na jiki, sau biyu a rana, don kwanaki 3-5 a jere: 50-75mg na kifi, sau ɗaya a rana, don 3-5 kwanaki a jere.

Wannan samfurin yana da takamaiman tasirin rigakafi lokacin amfani da shi a sashi sama da adadin da aka ba da shawarar.

(1) Kada a yi amfani da kajin da ke yin ƙwai don cin mutum a lokacin da ake yin shi.
(2) A yi amfani da kajin kiwon da hankali. Yana da embryotoxicity, kuma ya kamata a yi amfani da hankali ga dabbobi a lokacin daukar ciki da kuma lactation.
(3) An haramta amfani da dabba a lokacin alurar riga kafi ko kuma lokacin da aikin rigakafi ya yi rauni sosai.
(4) Wajibi ne a rage yawan adadin ko kuma tsawaita lokacin gudanarwa ga dabbobin da ke fama da gazawar koda.

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