I-Florfenicol powder

 i-florfenicol

Lo mkhiqizo umhlophe noma ucishe ube yimpushana emhlophe.

I-Pharmacodynamics: I-florfenicol ingeyama-antibiotic abanzi we-amide alcohols nama-bacteriostatic agents. Idlala indima ngokuhlanganisa ne-ribosomal 50S subunit ukuvimbela ukuhlanganiswa kwephrotheni yebhaktheriya. Inomsebenzi oqinile we-antibacterial ngokumelene nezinhlobonhlobo zamagciwane e-gram-positive kanye ne-gram-negative. I-Pasteurella haemolytica, i-Pasteurella multocida kanye ne-Actinobacillus pleuropneumoniae zazizwela kakhulu i-florfenicol. I-In vitro, umsebenzi we-antibacterial we-florfenicol ngokumelene nama-microorganisms amaningi ufana noma unamandla kunalowo we-thiamphenicol. Amanye amagciwane amelana ne-amide alcohols ngenxa ye-acetylation, njenge-Escherichia coli, i-Klebsiella pneumoniae, angase azwele ku-florfenicol.

Isetshenziselwa ikakhulukazi izifo ezibangelwa amagciwane ezingulube, izinkukhu nezinhlanzi ezibangelwa amagciwane azwelayo, afana ne-Pasteurella haemolytica, i-Pasteurella multocida kanye nezifo zokuphefumula kwezinkomo nezingulube ezibangelwa i-Actinobacillus pleuropneumoniae. I-Salmonella I-typhoid ne-paratyphoid fever, ikholera yenkukhu, i-pullorum yenkukhu, isifo se-Escherichia coli, njll; I-Fish bacterial septicemia, i-enteritis, isikhumba esibomvu esibangelwa i-Pasteurella, Vibrio, Staphylococcus aureus, Hydromonas, amagciwane e-enteritis, njll Ukugula, njll.

I-Pharmacokinetics I-Flufenicol ingamuncwa ngokushesha ngemuva kokuphathwa ngomlomo, futhi ukugxila kokwelapha kungafinyelelwa egazini cishe ihora eli-1 kamuva, futhi ukuhlushwa okuphezulu kwe-plasma kungafinyelelwa kungakapheli amahora angama-1-3. I-bioavailability ingaphezu kwama-80%. I-Flofenicol isatshalaliswa kabanzi ezilwaneni futhi ingaba Ngokuvimbela igazi nobuchopho. Ikhishwa ikakhulukazi emchameni ngendlela yokuqala, futhi inani elincane likhishwa ngendle.

(1) Ama-Macrolides nama-lincomamine anethagethi yesenzo efanayo njengalo mkhiqizo, womabili abophezelekile ku-50S subunit ye-ribosome yebhaktheriya, futhi angaveza ukuphikisa lapho esetshenziswa ndawonye.
(2) Ingase ixabanise umsebenzi wokubulala amagciwane we-penicillin noma izidakamizwa ze-aminoglycoside, kodwa akufakazelwanga ezilwaneni.

I-Amide alcohol antibiotics. Ngezifo ze-Pasteurella ne-Escherichia coli.

Kubalwe yilo mkhiqizo. Ukuphathwa ngomlomo: 0.1-0.15g ezingulubeni nezinkukhu nge-1kg isisindo somzimba, kabili ngosuku, izinsuku ezingu-3-5 ezilandelanayo: 50-75mg izinhlanzi, kanye ngosuku, izinsuku ezingu-3-5 ezilandelanayo.

Lo mkhiqizo unomphumela othile we-immunosuppressive uma usetshenziswa ngethamo elingaphezu komthamo onconyiwe.

(1) Izinkukhu ezizalela amaqanda ukuze zidliwe abantu akufanele zisetshenziswe ngesikhathi sokuzalela.
(2) Izinkukhu ezizalayo kufanele zisetshenziswe ngokuqapha. Ine-embryotoxicity, futhi kufanele isetshenziswe ngokuqapha emfuyweni ngesikhathi sokukhulelwa nokuncelisa.
(3) Akuvunyelwe ukusebenzisa isilwane ngesikhathi sokugoma noma lapho umsebenzi wokuzivikela omzimba ukhubazekile kakhulu.
(4) Kudingekile ukunciphisa umthamo noma ukwelula isikhathi sokuphatha ezilwaneni ezinokwehluleka kwezinso.

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