Umgubo weFlorfenicol

 iflorfenicol

Le mveliso imhlophe okanye iphantse ibe ngumgubo omhlophe.

I-Pharmacodynamics: i-florfenicol yeye-antibiotics ebanzi ye-amide alcohols kunye ne-bacteriostatic agents. Idlala indima ngokudibanisa ne-ribosomal 50S subunit ukuvimbela ukuhlanganiswa kweprotheni yebhaktheriya. Inomsebenzi onamandla we-antibacterial ngokuchasene neentlobo zebhaktheriya zegram-positive kunye negram-negative. I-Pasteurella haemolytica, i-Pasteurella multocida kunye ne-Actinobacillus pleuropneumoniae zazinovelwano kakhulu kwi-florfenicol. I-In vitro, umsebenzi we-antibacterial we-florfenicol ngokuchasene ne-microorganisms ezininzi ufana okanye unamandla kunalowo we-thiamphenicol. Ezinye iibhaktheriya ezikwaziyo ukumelana ne-amide alcohols ngenxa ye-acetylation, efana ne-Escherichia coli, i-Klebsiella pneumoniae, isenokuba novelwano kwi-florfenicol.

Isetyenziswa kakhulu kwizifo zebhaktiriya zeehagu, iinkukhu kunye neentlanzi ezibangelwa ziintsholongwane ezibuthathaka, ezifana nePasteurella haemolytica, Pasteurella multocida kunye nezifo zokuphefumla zenkomo neehagu ezibangelwa yi Actinobacillus pleuropneumoniae. I-Salmonella I-Typhoid kunye ne-paratyphoid fever, ikholera yenkukhu, i-pullorum yenkukhu, isifo se-Escherichia coli, njl. I-septicemia yebhaktiriya yeentlanzi, i-enteritis, isikhumba esibomvu esibangelwa yi-Pasteurella, i-Vibrio, i-Staphylococcus aureus, i-Hydromonas, ibhaktheriya ye-enteritis, njl Ukugula, njl.

I-Pharmacokinetics I-Flufenicol inokuthatyathwa ngokukhawuleza emva kokulawulwa komlomo, kwaye ugxininiso lonyango lunokufikelelwa kwigazi malunga neyure eli-1 kamva, kwaye i-peak concentration ye-plasma inokufikelela kwiiyure ze-1 ~ 3. I-bioavailability ingaphezulu kwe-80%. I-Flofenicol isasazwa ngokubanzi kwizilwanyana kwaye inokuthi Ngokusebenzisa umqobo wegazi-ubuchopho. Ikakhulu ikhutshwe kumchamo kwifom yokuqala, kwaye ixabiso elincinci likhutshwa ngamandle.

(1) IiMacrolides kunye ne-lincomamines zineentshukumo ezifanayo ekujoliswe kuzo njengale mveliso, zombini zibotshelelwe kwi-50S subunit ye-ribosome yebhaktiriya, kwaye inokuvelisa inkcaso efanayo xa isetyenziswa kunye.
(2) Isenokuchasa umsebenzi we-bactericidal we-penicillin okanye i-aminoglycoside amayeza, kodwa ayikabonakaliswa kwizilwanyana.

Amide antibiotics utywala. Kuba usulelo lwe-Pasteurella kunye ne-Escherichia coli.

Kubalwa yile mveliso. Ukulawulwa komlomo: 0.1-0.15g yeehagu kunye neenkukhu nge-1kg ubunzima bomzimba, kabini ngosuku, iintsuku ezi-3-5 ezilandelelanayo: 50-75mg yeentlanzi, kanye ngosuku, iintsuku ezi-3-5 ezilandelelanayo.

Le mveliso inefuthe elithile lokukhusela umzimba xa lisetyenziswa kwidosi ephezulu kunedosi ecetyiswayo.

(1) Iinkukhu ezizalela amaqanda ukuze zityiwe ngabantu aziyi kusetyenziswa ngexesha lokubeka.
(2) Iinkukhu ezizalayo kufuneka zisetyenziswe ngononophelo. Ine-embryotoxicity, kwaye kufuneka isetyenziswe ngononophelo kwimfuyo ngexesha lokukhulelwa kunye nokuncancisa.
(3) Akuvunyelwe ukusebenzisa isilwanyana ngexesha lokugonywa okanye xa umsebenzi we-immune uphazamiseka kakhulu.
(4) Kuyimfuneko ukunciphisa umthamo okanye ukwandisa ixesha lolawulo lwezilwanyana ezinokusilela kwezintso.

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