Ifu ya Florfenicol

 florfenicol

Ibicuruzwa byera cyangwa ifu yera hafi.

Pharmacodynamics: florfenicol ni antibiyotike yagutse ya antibiyotike ya amide alcohol na bacteriostatic. Ifite uruhare muguhuza na ribosomal 50S subunit kugirango ibuze synthesis ya proteine ​​ya bagiteri. Ifite ibikorwa bikomeye bya antibacterial kurwanya bagiteri zitandukanye-nziza na bagiteri-mbi. Pasteurella haemolytica, Pasteurella multocida na Actinobacillus pleuropneumoniae bumvaga cyane florfenicol. Muri vitro, ibikorwa bya antibacterial ya florfenicol irwanya mikorobe nyinshi birasa cyangwa bikomeye kuruta ibya thiamphenicol. Bagiteri zimwe na zimwe zirwanya amide alcool bitewe na acetylation, nka Escherichia coli, Klebsiella pneumoniae, irashobora gukomeza kumva florfenicol.

Ikoreshwa cyane cyane mu ndwara ziterwa na bagiteri z'ingurube, inkoko n'amafi ziterwa na bagiteri zoroshye, nka Pasteurella haemolytica, Pasteurella multocida n'indwara z'ubuhumekero z'inka n'ingurube zatewe na Actinobacillus pleuropneumoniae. Salmonella Tifoyide na paratyphoide umuriro, kolera yinkoko, igikurura inkoko, indwara ya Escherichia coli, nibindi; Amafi ya bacteri septicemia, enteritis, uruhu rutukura rwatewe na Pasteurella, Vibrio, Staphylococcus aureus, Hydromonas, bacteri za enteritis, nibindi Uburwayi, nibindi.

Pharmacokinetics Flufenicol irashobora kwinjizwa vuba nyuma yubuyobozi bwo mu kanwa, kandi imiti yo kuvura irashobora kugerwaho mumaraso nyuma yisaha 1, kandi plasma yibipimo irashobora kugerwaho mugihe cyamasaha 1 ~ 3. Bioavailability iri hejuru ya 80%. Florfenicol ikwirakwizwa cyane mu nyamaswa kandi irashobora Binyuze kuri barrière yamaraso. Isohoka cyane cyane mu nkari muburyo bwumwimerere, kandi umubare muto usohoka hamwe numwanda.

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(2) Irashobora kurwanya ibikorwa bya bagiteri yica imiti ya penisiline cyangwa aminoglycoside, ariko ntabwo byagaragaye mubikoko.

Hagati ya antibiyotike ya alcool. Kubyanduye Pasteurella na Escherichia coli.

Kubarwa niki gicuruzwa. Ubuyobozi bwo mu kanwa: 0.1-0.15g ku ngurube n'inkoko ku buremere bw'umubiri 1 kg, kabiri ku munsi, mu minsi 3-5 ikurikiranye: 50-75mg ku mafi, rimwe ku munsi, mu minsi 3-5 ikurikiranye.

Iki gicuruzwa gifite ingaruka zo gukingira indwara iyo gikoreshejwe kuri dosiye irenze igipimo cyasabwe.

(1) Inkoko zitera amagi kugirango abantu barye ntizishobora gukoreshwa mugihe cyo gutera.
(2) Ubworozi bw'inkoko bugomba gukoreshwa ubwitonzi. Ifite insoro, kandi igomba gukoreshwa mubwitonzi bwamatungo mugihe utwite no konsa.
(3) Birabujijwe gukoresha inyamaswa mugihe cyinkingo cyangwa mugihe imikorere yumubiri yangiritse cyane.
(4) Birakenewe kugabanya urugero cyangwa kongera intera yubuyobozi bwinyamaswa zidafite impyiko.

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