Levamisole 1000 MG
Pharmacokinetics
Levamisole yana tsotse daga hanji bayan yin alluran baki da kuma ta fata bayan aikace-aikacen dermal, kodayake bioavailabilities suna canzawa. An ba da rahoton cewa an rarraba shi a cikin jiki. Levamisole yana haɓaka da farko tare da ƙasa da kashi 6% ba tare da canzawa ba a cikin fitsari. An ƙayyade rabin rayuwa na kawar da Plasma don nau'in dabbobi da yawa: Shanu 4-6 hours; Karnuka 1.8-4 hours; da alade 3.5-6.8 hours. Metabolites suna fitar da su a cikin fitsari (na farko) da najasa.
Alamu
Ana nuna Levamisole don maganin nematodes da yawa a cikin shanu, tumaki & awaki, alade, kaji. A cikin tumaki da shanu, levamisole yana da ingantacciyar aiki mai kyau akan nematodes abomasal, ƙananan nematodes na hanji (ba su da kyau musamman akan Strongyloides spp.), manyan nematodes na hanji (ba Trichuris spp.), da lungworms. Babban nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i-nau'i) rufe: Haemonchus spp.,Trichostrongylus spp., Osteragia spp.,Coria spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., Chabertia spp., da Dictyocaulus vivapurus. Levamisole ba shi da tasiri a kan nau'ikan da ba su da girma na waɗannan ƙwayoyin cuta kuma gabaɗaya baya tasiri a cikin shanu (amma ba tumaki ba) a kan nau'ikan tsutsa da aka kama.
A cikin alade, ana nuna levamisole don maganin Ascaris suum, Oesophagostomum spp., Strongyloides, Stephanurus, da Metastrongylus.
An yi amfani da Levamisole a cikin karnuka a matsayin microfilaricide don magance cutar Dirofilaria immitis.
Contraindications / Kariya
Levamisole an hana shi a cikin dabbobi masu shayarwa. Ya kamata a yi amfani da shi a hankali, idan ma, a cikin dabbobin da ke da rauni sosai, ko kuma suna da nakasar koda ko hanta. Yi amfani da hankali ko, zai fi dacewa, jinkirta amfani a cikin dabbobin da ke cikin damuwa saboda alurar riga kafi, baƙar fata ko simintin gyare-gyare.
Babu bayani game da amincin wannan magani a cikin dabbobi masu ciki. Ko da yake ana ɗaukar levamisole ingantacciyar lafiya don amfani a cikin manyan dabbobin da ke da juna biyu, yi amfani da shi kawai idan fa'idodin da za a iya amfani da su ya fi haɗarin haɗari.
Mummunan Tasiri/Gargadi
Mummunan illolin da za a iya gani a cikin shanu na iya haɗawa da kumfa-ƙumfa ko hypersalivation, jin daɗi ko rawar jiki, lasar leɓe da girgiza kai. Ana lura da waɗannan tasirin gabaɗaya tare da sama da allurai da aka ba da shawarar ko kuma idan ana amfani da levamisole tare da organophosphates. Alamun gabaɗaya suna raguwa a cikin sa'o'i 2. Lokacin yin allurar cikin shanu, kumburi na iya faruwa a wurin allurar. Wannan yawanci zai ragu a cikin kwanaki 7-14, amma yana iya zama abin ƙyama a cikin dabbobin da ke kusa da yanka.
A cikin tumaki, levamisole na iya haifar da tashin hankali a wasu dabbobi bayan an yi allurai. A cikin awaki, levamisole na iya haifar da damuwa, hyperesthesia da salivation.
A cikin alade, levamisole na iya haifar da salivation ko kumfa. Alade da suka kamu da tsutsotsin huhu na iya haifar da tari ko amai.
Abubuwan da za a iya gani a cikin karnuka sun hada da rikicewar GI (yawanci amai, zawo), neurotoxicity (panting, girgiza, tashin hankali ko wasu canje-canje na hali), agranulocytosis, dyspnea, edema na huhu, fashewar fata mai tsaka-tsaki (erythroedema, erythema multiforme, mai guba). epidermal necrolysis) da kuma lethargy.
Mummunan illa da ake gani a cikin kuliyoyi sun haɗa da hypersalivation, tashin hankali, mydriasis da amai.
Sashi da Gudanarwa
Domin gudanar da baki.
Babban sashi shine 5-7.5 MG Levamisole kowace kilogiram na nauyin jiki.
Don ƙarin cikakkun bayanai masu alaƙa da kowane bolus, duba tebur a ƙasa.
Maganin Bolus:
150mg 1 bolus da 25kg nauyi na jiki.
600mg 1 bolus da 100kg nauyi na jiki.
1000mg 1 bolus da 150kg nauyi na jiki.
Lokacin Janyewa
Shanu (nama & nama): kwanaki 5.
Tumaki (nama & nama): kwanaki 5.
Kada a yi amfani da shi a cikin dabbobin da ke samar da madara don amfanin ɗan adam.
Adana
Matsakaicin zafin ajiya da aka ba da shawarar shine 30 ℃.
Gargaɗi: Ka kiyaye nesa da yara.
Labarai
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