Levamisole 1000mg Bolus

Hoʻopili ʻia ʻo Levamisole mai ka ʻōpū ma hope o ka hoʻohana ʻana i ka waha a ma o ka ʻili ma hope o ka hoʻohana ʻana i ka dermal, ʻoiai he mau bioavailability. Ua hōʻike ʻia ua puʻunaue ʻia ma ke kino. Hoʻopili mua ʻia ʻo Levamisole me ka liʻiliʻi o 6% i hoʻokuʻu ʻia me ka loli ʻole i ka mimi. Ua hoʻoholo ʻia ka hapalua o ka hoʻopau ʻana i ka plasma no kekahi mau ʻano holoholona: Pipi 4-6 hola; Nā'īlio 1.8-4 hola; a me ka puaʻa 3.5-6.8 hola. Hoʻokuʻu ʻia nā metabolites i loko o ka mimi (ma mua) a me nā feces.

Hōʻike ʻia ʻo Levamisole no ka mālama ʻana i nā nematodes he nui i nā pipi, hipa & kao, puaʻa, moa. I loko o nā hipa a me nā pipi, he hana maikaʻi loa ka levamisole e kūʻē i nā nematodes abomasal, nā nematodes ʻōpū liʻiliʻi (ʻaʻole maikaʻi loa iā Strongyloides spp.), nā nematodes ʻōpū nui (ʻaʻole Trichuris spp.), a me nā lungworms. ʻO nā ʻano makua o nā ʻano mea i uhi mau ʻia e levamisole, ʻo ia hoʻi: Haemonchus spp., Trichostrongylus spp., Osteragia spp., Cooperia spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., Chabertia spp., a me Dictyocaulus vivapurus. ʻAʻole ʻoi aku ka maikaʻi o ka Levamisole e kūʻē i nā ʻano ʻokoʻa ʻole o kēia mau palaʻai a ʻaʻole maikaʻi i nā pipi (akā ʻaʻole nā ​​hipa) i nā ʻano larval i hopu ʻia.

I ka puaʻa, hōʻike ʻia ka levamisole no ka mālama ʻana iā Ascaris suum, Oesophagostomum spp., Strongyloides, Stephanurus, a me Metastrongylus.

Ua hoʻohana ʻia ʻo Levamisole i nā ʻīlio ma ke ʻano he microfilaricide e mālama i ka maʻi Dirofilaria immitis.

Hoʻopaʻa ʻia ʻo Levamisole i nā holoholona lactating. Pono e hoʻohana me ka akahele, inā loaʻa, i nā holoholona i nāwaliwali loa, a i ʻole i loaʻa i ka maʻi renal a i ʻole hepatic nui. E hoʻohana me ka akahele a i ʻole, ʻoi aku ka maikaʻi, e hoʻopaneʻe i ka hoʻohana ʻana i nā pipi i koʻikoʻi ma muli o ka lāʻau lapaʻau, hoʻoneʻe ʻia a i ʻole castration.

ʻAʻohe ʻike e pili ana i ka palekana o kēia lāʻau i nā holoholona hāpai. ʻOiai ua manaʻo ʻia ʻo levamisole he palekana no ka hoʻohana ʻana i nā holoholona nui e hāpai ana, e hoʻohana wale inā ʻoi aku ka nui o nā pōmaikaʻi ma mua o nā pilikia.

ʻO nā hopena maikaʻi ʻole i ʻike ʻia i loko o nā pipi e hiki ke komo i ka muzzle-foaming a i ʻole hypersalivation, hauʻoli a haʻalulu, lehelehe a me ka lulu poʻo. Hoʻomaopopo pinepine ʻia kēia mau hopena me ka kiʻekiʻe aʻe o nā dosis i ʻōlelo ʻia a inā hoʻohana ʻia ka levamisole me nā organophosphates. Hoʻopau maʻamau nā hōʻailona i loko o 2 mau hola. Ke hoʻokomo ʻia i loko o ka pipi, hiki mai ka pehu ma ka wahi i hoʻopaʻa ʻia. E emi ana kēia i loko o 7-14 mau lā, akā hiki ke hōʻole ʻia i nā holoholona kokoke i ka luku.

 I nā hipa, hiki i ka levamisole ke hoʻoulu i kekahi mau holoholona ma hope o ka lawe ʻana. I nā kao, hiki i ka levamisole ke hoʻoulu i ke kaumaha, hyperesthesia a me ka salivation.
 I loko o ka puaʻa, hiki i ka levamisole ke hoʻoulu i ka salivation a i ʻole ka hū ʻana o ka waha. Hiki i ka puaʻa i loaʻa i ka ʻiʻo maʻi maʻi i ka ʻū a me ka luaʻi.

 ʻO nā hopena maikaʻi ʻole i ʻike ʻia i loko o nā ʻīlio, ʻo ia ka pilikia GI (maʻamau ka luaʻi ʻana, ka maʻi paʻi), neurotoxicity (panting, haʻalulu, agitation a me nā loli ʻē aʻe), agranulocytosis, dyspnea, pulmonary edema, immune-mediated eruptions ʻili (erythroedema, erythema multiforme, toxic epidermal necrolysis) a me ka lethargy.

 ʻO nā hopena maikaʻi ʻole i ʻike ʻia i nā pōpoki ʻo ia ka hypersalivation, hauʻoli, mydriasis a me ka luaʻi.
 

No ka hooponopono waha.

ʻO ka maʻamau maʻamau ʻo 5-7.5 mg Levamisole no ke kaumaha o ke kino.

No nā kikoʻī kikoʻī e pili ana i kēlā me kēia bolus, e ʻike i ka papa ma lalo.

ʻO ka hoʻohana Bolus:

150mg 1 bolus no 25kg kaumaha kino.

600mg 1 bolus no 100kg paona kino.

1000mg 1 bolus no 150kg paona kino.

Pipi (ʻiʻo a me waho): 5 lā.

hipa (ʻiʻo a me ka ʻiʻo): 5 lā.

ʻAʻole e hoʻohana ʻia i nā holoholona e hana ana i ka waiū no ka ʻai kanaka.

ʻO 30 ℃ ka wela o ka mālama ʻana.

'Ōlelo Aʻo: E mālama i waho o nā keiki.