Levamisole 1000mg Bolus

Levamisole imatengedwa kuchokera m'matumbo pambuyo pa kulowetsedwa m'kamwa komanso kudzera pakhungu pambuyo popaka pakhungu, ngakhale kuti bioavailabilities imasinthasintha. Akuti amagawidwa m'thupi lonse. Levamisole makamaka zimapukusidwa ndi zosakwana 6% excreted osasintha mu mkodzo. Kuchotsa plasma theka la miyoyo yatsimikiziridwa kwa mitundu ingapo ya zinyama: Ng'ombe maola 4-6; Agalu 1.8-4 maola; ndi Nkhumba 3.5-6.8 maola. Ma metabolites amachotsedwa mumkodzo (makamaka) ndi ndowe.

Levamisole amasonyezedwa pofuna kuchiza ambiri nematodes ng'ombe, nkhosa ndi mbuzi, nkhumba, nkhuku. Mu nkhosa ndi ng’ombe, levamisole imakhala ndi ntchito yabwino yolimbana ndi abomasal nematodes, nematodes ya m’matumbo aang’ono (osati yabwino kwambiri motsutsana ndi Strongyloides spp.), nematodes ya m’matumbo aakulu (osati Trichuris spp.), ndi mphutsi za m’mapapo. Mitundu ya anthu akuluakulu omwe nthawi zambiri amaphimbidwa ndi levamisole, ndi awa: Haemonchus spp., Trichostrongylus spp., Osteragia spp., Cooperia spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., Chabertia spp., ndi Dictyopuulus. Levamisole sagwira ntchito kwambiri polimbana ndi tizilombo toyambitsa matenda ndipo nthawi zambiri sagwira ntchito pa ng'ombe (koma osati nkhosa) polimbana ndi mphutsi zomangidwa.

Mu nkhumba, levamisole amasonyezedwa pochiza Ascaris suum, Oesophagostomum spp., Strongyloides, Stephanurus, ndi Metastrongylus.

Levamisole wakhala akugwiritsidwa ntchito kwa agalu ngati microfilaricide pochiza matenda a Dirofilaria immitis.

Levamisole ndi contraindicated mu lactating nyama. Ayenera kugwiritsidwa ntchito mosamala, ngati kuli kotheka, kwa nyama zomwe zafooka kwambiri, kapena zomwe zili ndi vuto lalikulu la aimpso kapena chiwindi. Gwiritsani ntchito mosamala kapena, makamaka, muchedwetse kugwiritsa ntchito ng'ombe zomwe zapanikizika chifukwa cha katemera, kuchotsa nyanga kapena kuthena.

Palibe zambiri zokhudza chitetezo cha mankhwalawa mu nyama zapakati. Ngakhale kuti levamisole imaonedwa kuti ndi yotetezeka kugwiritsa ntchito nyama zazikulu zomwe zili ndi pakati, zigwiritseni ntchito pokhapokha ngati phindu lomwe lingakhalepo likuposa zoopsa zake.

Zotsatira zoyipa zomwe zingawoneke pa ng'ombe zingaphatikizepo kutulutsa thovu kapena hypersalivation, chisangalalo kapena kunjenjemera, kunyambita milomo ndi kugwedeza mutu. Izi nthawi zambiri zimazindikirika ndi mlingo wapamwamba kuposa wovomerezeka kapena ngati levamisole imagwiritsidwa ntchito limodzi ndi organophosphates. Zizindikiro zimachepa pakatha maola awiri. Pobaya ng'ombe, kutupa kumatha kuchitika pamalo obaya jakisoni. Izi nthawi zambiri zimatha pakadutsa masiku 7-14, koma zitha kukhala zotsutsana ndi nyama zomwe zatsala pang'ono kuphedwa.

 Mu nkhosa, levamisole angayambitse kwakanthawi excitability nyama zina pambuyo mlingo. Mu mbuzi, levamisole zingachititse maganizo, hyperesthesia ndi salivation.
 Mu nkhumba, levamisole angayambitse malovu kapena thovu pakamwa. Nkhumba zomwe zili ndi mphutsi za m'mapapo zimatha kutsokomola kapena kusanza.

 Zotsatira zoyipa zomwe zingawonekere mwa agalu ndi monga kusokonezeka kwa GI (nthawi zambiri kusanza, kutsekula m'mimba), neurotoxicity (kupuma, kugwedezeka, kukwiya kapena kusintha kwina kwamakhalidwe), agranulocytosis, dyspnea, pulmonary edema, kuphulika kwapakhungu kwa chitetezo chamthupi (erythroedema, erythema multiforme, poizoni. epidermal necrolysis) ndi kuledzera.

 Zotsatira zoyipa zomwe zimawonedwa mwa amphaka zimaphatikizapo hypersalivation, chisangalalo, mydriasis ndi kusanza.
 

Kuwongolera pakamwa.

Mlingo wambiri ndi 5-7.5 mg wa Levamisole pa kilogalamu ya thupi.

Kuti mudziwe zambiri zokhudzana ndi bolus iliyonse, onani tebulo pansipa.

Mlingo wa Bolus:

150mg 1 bolus pa 25kg kulemera kwa thupi.

600mg 1 bolus pa 100kg kulemera kwa thupi.

1000mg 1 bolus pa 150kg kulemera kwa thupi.

Ng'ombe (nyama & offal): masiku 5.

Nkhosa (nyama & offal): masiku 5.

Osagwiritsidwa ntchito pa nyama zopanga mkaka kuti anthu azidya.

Kutentha kokwanira kosungirako ndi 30 ℃.

Chenjezo: Khalani kutali ndi ana.