Levamisole 1000mg Bolus

Levamisole yakuwe mu mara nyuma yo kunywa mu kanwa no mu ruhu nyuma yo kuyikoresha dermal, nubwo bioavailability ishobora guhinduka. Bivugwa ko ikwirakwizwa mu mubiri. Levamisole ikoreshwa cyane cyane hamwe na 6% isohoka idahindutse mu nkari. Kurandura plasma igice cyubuzima cyagenwe kubwoko butandukanye bwamatungo: Inka amasaha 4-6; Imbwa amasaha 1.8-4; n'ingurube amasaha 3.5-6.8. Metabolite isohoka mu nkari zombi (cyane cyane) n'umwanda.

Levamisole yerekanwa kuvura nematode nyinshi mu nka, intama & ihene, ingurube, inkoko. Mu ntama no mu nka, levamisole ifite ibikorwa byiza birwanya nematode abomasal, nematode ntoya yo munda (ntabwo ari byiza cyane kurwanya Strongyloides spp.), Nematode nini yo munda (ntabwo ari Trichuris spp.), N'ibihaha. Ubwoko bwabantu bakuze busanzwe butwikiriwe na levamisole, harimo: Haemonchus spp., Trichostrongylus spp., Osteragia spp., Cooperia spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., Chabertia spp., Na Dictyocaulus vivapurus. Levamisole ntigikora neza kurwanya imiterere idakuze yiyi parasite kandi muri rusange ntigikora neza inka (ariko ntabwo ari intama) kurwanya ifaranga zafashwe.

Mu ngurube, levamisole yerekanwa mu kuvura Ascaris suum, Oesophagostomum spp., Strongyloides, Stephanurus, na Metastrongylus.

Levamisole yakoreshejwe mu mbwa nka microfilaricide mu kuvura indwara ya Dirofilariya.

Levamisole yandujwe ninyamaswa zonsa. Bikwiye gukoreshwa ubwitonzi, niba aribyo byose, mubikoko byacitse intege cyane, cyangwa bifite impyiko zikomeye cyangwa umwijima. Koresha ubwitonzi cyangwa, nibyiza, gutinda gukoresha inka zishimangiwe kubera gukingirwa, kwangiza cyangwa guta.

Nta makuru yerekeye umutekano wibi biyobyabwenge ku nyamaswa zitwite. Nubwo levamisole ifatwa nkaho ifite umutekano mukoresha inyamaswa nini zitwite, koresha gusa niba inyungu zishobora kurenza ingaruka.

Ingaruka mbi zishobora kugaragara mu nka zirashobora kuba zirimo umunwa-ifuro cyangwa hypersalivation, umunezero cyangwa guhinda umushyitsi, gukuna iminwa no kuzunguza umutwe. Izi ngaruka zigaragara muri rusange kurenza urugero rusabwa cyangwa niba levamisole ikoreshwa hamwe na organofosifate. Ibimenyetso muri rusange bigabanuka mumasaha 2. Iyo utera inka, kubyimba birashobora kugaragara aho batewe. Ibi mubisanzwe bizagabanuka muminsi 7-14, ariko birashobora kutemerwa mubikoko byegereye kubagwa.

 Mu ntama, levamisole irashobora gutera umunezero wigihe gito mubikoko bimwe na bimwe nyuma yo kunywa. Ihene, levamisole irashobora gutera depression, hyperesthesia na salivation.
 Mu ngurube, levamisole irashobora gutera amacandwe cyangwa umunwa. Ingurube zanduye ibihaha zirashobora gukorora cyangwa kuruka.

 Ingaruka mbi zishobora kugaragara mu mbwa zirimo imvururu za GI (ubusanzwe kuruka, impiswi), neurotoxicity (panting, kunyeganyega, guhagarika umutima cyangwa izindi mpinduka zimyitwarire), agranulocytose, dyspnea, impyiko yindwara, kuruka k'uruhu (erythroedema, erythema multiforme, toxic) epidermal necrolysis) hamwe n'ubunebwe.

 Ingaruka mbi zigaragara mu njangwe zirimo hypersalivation, kwishima, mydriasis no kuruka.
 

Kubuyobozi bwo munwa.

Igipimo rusange ni 5-7.5 mg Levamisole kuri kg ibiro.

Kubindi bisobanuro birambuye bijyanye na buri bolus, reba imbonerahamwe ikurikira.

Bolus Dosage ：

150mg 1 bolus kuri 25 kg ibiro byumubiri.

600mg 1 bolus kubiro 100 kg.

1000mg 1 bolus kubiro 150 kg.

Inka (inyama & offal): iminsi 5.

Intama (inyama & offal): iminsi 5.

Ntabwo ugomba gukoreshwa mubikoko bitanga amata yo kurya abantu.

Ubushyuhe ntarengwa busabwa ni 30 ℃.

Iburira ： Ntugere kure y'abana.