Levamisole 1000mg Bolus
Pharmacokinetics
Levamisole e monngoa ka maleng ka mor'a ho noa ka molomo le ka letlalo ka mor'a ho sebelisoa ha letlalo, le hoja bioavailabilities e fetoha. Ho tlalehoa hore e ajoa 'meleng kaofela. Levamisole haholo-holo e metabolized ka tlase ho 6% excreted e sa fetoha ka moroto. Ho felisoa ha halofo ea bophelo ba plasma ho 'nile ha khethoa bakeng sa mefuta e mengata ea liphoofolo tsa liphoofolo: Likhomo lihora tse 4-6; Lintja lihora tse 1.8-4; le Swine lihora tse 3.5-6.8. Li-metabolites li ntšoa ka har'a moroto (haholo-holo) le mantleng.
Lipontšo
Levamisole e bontšoa bakeng sa phekolo ea li-nematodes tse ngata likhomo, linku le lipōli, likolobe, likhoho. Linku le likhomo, levamisole e na le ts'ebetso e batlang e le ntle khahlanong le abomasal nematodes, nematodes ea mala a manyane (ha e ntle haholo khahlanong le Strongyloides spp.), nematodes ea mala a maholo (eseng Trichuris spp.), le lungworms. Mefuta ea batho ba baholo e atisang ho koaheloa ke levamisole, e kenyelletsa: Haemonchus spp., Trichostrongylus spp., Osteragia spp., Cooperia spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., Chabertia spp., le Dictyopuulus. Levamisole ha e sebetse hantle kgahlanong le mefuta e sa holang ya dikokwana-hloko tsena mme ka kakaretso ha e sebetse dikgomong (empa e seng dinku) kgahlanong le mefuta ya dibokwana tse tshwerweng.
Ka likolobe, levamisole e bontšoa bakeng sa phekolo ea Ascaris suum, Oesophagostomum spp., Strongyloides, Stephanurus, le Metastrongylus.
Levamisole e 'nile ea sebelisoa ho lintja e le microfilaricide ho phekola tšoaetso ea Dirofilaria immitis.
Contraindications/Litlhokomelo
Levamisole e hanana le liphoofolo tse anyesang. E lokela ho sebelisoa ka hloko, haeba ho hang, ho liphoofolo tse holofetseng haholo, kapa tse nang le bokooa bo boholo ba renal kapa sebete. Sebelisa ka hloko kapa, ka ho khetheha, lieha ho sebelisoa likhomo tse nang le khatello ea kelello ka lebaka la ho entoa, ho tlosoa ha manaka kapa ho khaola.
Ha ho na tlhahisoleseding e mabapi le tšireletseho ea lithethefatsi ena ho liphoofolo tse nang le moimana. Le hoja levamisole e nkoa e batla e bolokehile hore e ka sebelisoa liphoofolong tse kholo tse emereng, e sebelise ha feela melemo e ka bang teng ho feta likotsi.
Liphello tse mpe/Litemoso
Liphello tse mpe tse ka bonoang likhomong li ka kenyelletsa ho ntša lefuba kapa hypersalivation, thabo kapa ho thothomela, ho nyeka molomo le ho sisinya hlooho. Litlamorao tsena hangata li bonoa ka litekanyetso tse phahameng ho feta tse khothaletsoang kapa haeba levamisole e sebelisoa ka nako e le 'ngoe le organophosphates. Hangata matšoao a kokobela nakong ea lihora tse peli. Ha u kenya likhomo ka likhomo, ho ruruha ho ka 'na ha etsahala sebakeng sa ente. Hangata sena se tla fela ka mor'a matsatsi a 7-14, empa e ka 'na ea e-ba ntho e sa utloahaleng ho liphoofolo tse haufi le ho hlajoa.
Linkung, levamisole e ka baka thabo ea nakoana liphoofolong tse ling ka mor'a ho noa. A lipōli, levamisole ka 'na etsa hore ho tepella maikutlo, hyperesthesia le salivation.
Likolobeng, levamisole e ka baka mathe kapa molomo o phophoma. Likolobe tse tšoaelitsoeng ke liboko li ka 'na tsa khohlela kapa tsa hlatsa.
Litlamorao tse mpe tse ka bonoang ho lintja li kenyelletsa litšitiso tsa GI (hangata ho hlatsa, letšollo), neurotoxicity (ho hemela, ho sisinyeha, ho ferekana kapa liphetoho tse ling tsa boitšoaro), agranulocytosis, dyspnea, pulmonary edema, ho phatloha ha letlalo ho tsoa ho 'mele (erythroedema, erythema multiforme, chefo). epidermal necrolysis) le lethargy.
Litlamorao tse mpe tse bonoang ho likatse li kenyelletsa hypersalivation, thabo, mydriasis le ho hlatsa.
Tekanyo le Tsamaiso
Bakeng sa tsamaiso ea molomo.
Tekanyetso e akaretsang ke 5-7.5 mg Levamisole ka kg ea boima ba 'mele.
Bakeng sa lintlha tse qaqileng haholoanyane tse amanang le bolus ka 'ngoe, bona tafole e ka tlase.
Tekanyetso ea Bolus:
150mg 1 bolus ka boima ba 'mele ba 25kg.
600mg 1 bolus ka boima ba 'mele ba 100kg.
1000mg 1 bolus ka boima ba 'mele ba 150kg.
Nako ea ho hula
Likhomo (nama & offal): matsatsi a 5.
Linku (nama & offal): matsatsi a 5.
Ha ea lokela ho sebelisoa liphoofolong tse hlahisang lebese bakeng sa ho jeoa ke batho.
Polokelo
Mocheso o phahameng o khothaletsoang oa polokelo ke 30℃.
Tlhokomeliso: Boloka moo bana ba ka fihlang teng.
Litaba
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