Neomycin Sulfate Soluble Powder
Neomycin sulfate
Sehlahisoa sena ke mofuta oa phofo e tšoeu ho isa mosehla o bobebe.
Pharmacodynamics Neomycin ke moriana o thibelang likokoana-hloko o nkiloeng ho hydrogen glycoside rice. Sehlahisoa sa eona sa antibacteria se tšoana le sa kanamycin. E na le phello e matla ea antibacterial ho libaktheria tse ngata tsa gram-negative, tse kang Escherichia coli, Proteus, Salmonella le Pasteurella multocida, hape e na le kutloelo-bohloko ho Staphylococcus aureus. Pseudomonas aeruginosa, libaktheria tsa gram-positive (ntle le Staphylococcus aureus), Rickettsia, anaerobes le li-fungus li hanyetsa sehlahisoa sena.
Pharmacokinetics Neomycin ha e monoe ka seoelo kamora ho tsamaisoa ka molomo le ts'ebeliso ea lehae. Kamora ho tsamaisoa ka molomo, ke 3% feela ea kakaretso ea neomycin e ntšoang morotong, 'me boholo ba eona e ntšoa mantleng ntle le phetoho. Intestinal mucosa ho ruruha kapa liso ka eketsa ho monya. Sethethefatsi se kenngoa kapele ka mor'a ente, 'me mokhoa oa eona oa ka hare o tšoana le oa kanamycin.
(1) Ha e kopantsoe le lithibela-mafu tsa macrolide, e ka phekola lefu la mastitis le bakoang ke baktheria ea gram-positive.
(2) Tsamaiso ea molomo e ka ama ho monya ha digitalis, vithamine A kapa vithamine B12.
(3) E na le phello ea synergistic le penicillin kapa cephalosporin.
(4) Tšusumetso ea antibacteria ea sehlahisoa sena e ntlafatsoa tikolohong ea alkaline, 'me e lumellana le lithethefatsi tsa alkaline (joalo ka sodium bicarbonate, aminophylline Joalo-joalo) e ka ntlafatsa phello ea antibacterial, empa chefo e boetse e ntlafatsoa ka tsela e tšoanang. Antibacterial ha pH e feta 8.4 Ho fapana le hoo, phello e fokotsehile.
(5) Li-cations tse kang Ca2 +, Mg2 +, Na +, NH le K + li ka thibela mosebetsi oa antibacterial oa sehlahisoa.
(6) Ha e kopantsoe le cephalosporin, dextran, diuretics tse matla (joaloka furosemide), erythromycin, joalo-joalo, e ka Ntlafatsa ototoxicity ea sehlahisoa sena.
(7) Li-relaxation tsa mesifa ea masapo (tse kang succinylcholine chloride) kapa lithethefatsi tse nang le phello ena li ka matlafatsa phello ea Neuromuscular block.
Likokoana-hloko tsa Aminoglycoside. Haholo-holo e sebelisoa ho omisa ho phekola tšoaetso ea ka mpeng e bakoang ke libaktheria tse nang le gram-negative.
E baloang ke sehlahisoa sena. Ho noa ho tsoakiloeng: 1.54 ~ 2.31g ea likhoho ka 1L ea metsi. E ka sebelisoa kamehla bakeng sa matsatsi a 3-5.
Neomycin ke chefo e ngata ka ho fetisisa ho aminoglycosides, empa ho na le liphetoho tse fokolang tse chefo ha e sebelisoa ka molomo kapa sebakeng sa heno.
Likhoho tse behelang mahe ho jeoa ke batho li ke ke tsa sebelisoa nakong ea ho behela.
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