Levamisole 1000mg Bolus

I-Levamisole ifunxwa emathunjini emva kokusetyenziswa komlomo kunye nolusu emva kokusetyenziswa kwe-dermal, nangona i-bioavailabilities iguquguquka. Kuthiwa isasazwa kuwo wonke umzimba. I-Levamisole ngokuyinhloko i-metabolized kunye ne-6% ekhutshiweyo engatshintshiyo kumchamo. Ukupheliswa kwesiqingatha-ubomi be-plasma kunqunywe kwiintlobo ezininzi zezilwanyana: Iinkomo 4-6 iiyure; Izinja 1.8-4 iiyure; kunye Swine 3.5-6.8 iiyure. I-Metabolites ikhutshwe kuzo zombini umchamo (ngokuyinhloko) kunye neendle.

I-Levamisole iboniswa kunyango lwe-nematodes ezininzi kwiinkomo, iigusha kunye neebhokhwe, iihagu, iinkukhu. Kwiigusha kunye neenkomo, i-levamisole inomsebenzi olungileyo ngokuchasene ne-abomasal nematodes, i-nematodes yamathumbu amancinci (ayilunganga kakhulu kwi-Strongyloides spp.), i-nematodes yamathumbu amakhulu (hayi i-Trichuris spp.), kunye ne-lungworms. Iintlobo zabantu abadala zeentlobo ezihlala zigutyungelwe yi-levamisole, ziquka: Haemonchus spp., Trichostrongylus spp., Osteragia spp., Cooperia spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., Chabertia spp., kunye neDivactyoruulus. ILevamisole ayisebenzi kangako kwiintlobo ezingekavuthwa zezi zimfimfithi kwaye ayisebenzi kwiinkomo (kodwa hayi iigusha) kwiifom zombungu obanjiweyo.

Kwihagu, i-levamisole iboniswa kunyango lwe-Ascaris suum, i-Oesophagostomum spp., i-Strongyloides, i-Stephanurus, kunye ne-Metastrongylus.

I-Levamisole isetyenziswe kwizinja njenge-microfilaricide ukunyanga i-Dirofilaria immitis yosulelo.

I-Levamisole ayivumelekanga kwizilwanyana ezincancisayo. Kufuneka isetyenziswe ngononophelo, ukuba kunjalo, kwizilwanyana ezibuthathaka kakhulu, okanye ezinokukhubazeka okubonakalayo kwezintso okanye kwesibindi. Sebenzisa ngononophelo okanye, ngokukhethekayo, ulibazise ukusetyenziswa kwiinkomo ezinoxinzelelo ngenxa yokugonywa, ukunqunyulwa kweempondo okanye ukuthenwa.

Akukho lwazi malunga nokhuseleko lweli chiza kwizilwanyana ezikhulelweyo. Nangona i-levamisole ithathwa njengekhuselekile ngokwentelekiso ukuba ingasetyenziswa kwizilwanyana ezikhulu ezimithiyo, sebenzisa kuphela ukuba uncedo olunokubakho lungaphezu kweengozi.

Imiphumo emibi enokuthi ibonakale kwiinkomo ingabandakanya i-muzzle-foaming okanye i-hypersalivation, uchulumanco okanye ukungcangcazela, ukukhupha umlomo kunye nokuxubha intloko. Ezi ziphumo ziphawulwa ngokubanzi ngeedosi eziphakamileyo kunezicetyiswayo okanye ukuba i-levamisole isetyenziswe ngokuhambelana ne-organophosphates. Iimpawu ziye ziphele kwiiyure ezi-2. Xa utofa iinkomo, ukudumba kunokuthi kwenzeke kwindawo yokutofa. Oku kudla ngokuphela kwiintsuku ezisi-7 ukuya kwezili-14, kodwa kusenokungafuneki kwizilwanyana ezikufutshane nokuxhelwa.

 Kwiigusha, i-levamisole inokubangela ukonwaba okwexeshana kwezinye izilwanyana emva kokudosa. Kwiibhokhwe, i-levamisole inokubangela ukudakumba, i-hyperesthesia kunye ne-salivation.
 Kwiihagu, i-levamisole inokubangela ukugalela amathe okanye umlomo ube namagwebu. Ihagu eyosulelwe yimisundululu inokubakho ukukhohlela okanye ukugabha.

 Iziphumo ezimbi ezinokuthi zibonwe ezinjeni ziquka ukuphazamiseka kwe-GI (ngokuqhelekileyo ukuhlanza, isifo sohudo), i-neurotoxicity (ukuphefumla, ukungcangcazela, ukuphazamiseka okanye ezinye iinguqu zokuziphatha), i-agranulocytosis, i-dyspnea, i-pulmonary edema, ukuqhuma kwesikhumba somzimba (i-erythroedema, i-erythema multiforme, ityhefu i-epidermal necrolysis) kunye nokutyhafa.

 Iziphumo ezibi ezibonwa kwiikati ziquka i-hypersalivation, uchulumanco, i-mydriasis kunye nokuhlanza.
 

Kulawulo lomlomo.

Idosi eqhelekileyo yi-5-7.5 mg Levamisole ngekhilogram yobunzima bomzimba.

Ngolwazi oluthe kratya oluthe kratya olunxulumene ne-bolus nganye, jonga itheyibhile engezantsi.

Umthamo we-Bolus:

150mg 1 bolus nganye 25kg ubunzima bomzimba.

600mg 1 bolus nge-100kg ubunzima bomzimba.

1000mg 1 bolus nganye 150kg ubunzima bomzimba.

Iinkomo (inyama kunye ne-offal): iintsuku ezi-5.

Iigusha (inyama kunye ne-offal): iintsuku ezi-5.

Akufunekanga isetyenziswe kwizilwanyana ezivelisa ubisi ukuze zisetyenziswe ngabantu.

Ubushushu bokugcina obucetyiswayo yi-30℃.

Isilumkiso:Yigcine kwindawo ekungafikeleli kuyo abantwana.