Erythromycin Thiocyanate Soluble Powder

Erythromycin

This product is white or almost white powder.

Pharmacodynamics Erythromycin is a macrolide antibiotic. The effect of this product on gram-positive bacteria is similar to penicillin, but its antibacterial spectrum is wider than penicillin. Sensitive gram-positive bacteria include Staphylococcus aureus (including penicillin resistant Staphylococcus aureus), pneumococcus, streptococcus, anthrax, erysipelas suis, listeria, clostridium putrescens, clostridium anthracis, etc. Sensitive gram-negative bacteria include Haemophilus influenzae, meningococcus, Brucella, Pasteurella, etc. In addition, it also has good effects on Campylobacter, Mycoplasma, Chlamydia, Rickettsia and Leptospira. The antibacterial activity of erythromycin thiocyanate in alkaline solution was enhanced. When the pH increased from 5.5 to 8.5, the antibacterial activity gradually increased. Pharmacokinetics Erythromycin base and stearate are easy to be degraded by gastric acid when taken orally. The type and dosage form of Erythromycin salt, the acidity of gastrointestinal tract and the food in stomach all affect its bioavailability. Only enteric coated preparations can be better absorbed. After absorption, it is widely distributed in various tissues and body fluids, but rarely enters into cerebrospinal fluid. The plasma protein binding rate is. 73%~81%。 A small part of erythromycin is metabolized as inactive N-methyl erythromycin in the liver, which is mainly excreted in prototype bile. Only 2%~5% of the dose is excreted in prototype urine.

(1) This product is not suitable for use at the same time as other macrolides and lincomamines because of the same target.

(2) When combined with B-lactam, it has antagonistic effect.

(3) It can inhibit the cytochrome oxidase system, and may inhibit its metabolism when used with some drugs.

Macrolide antibiotics. It is used to treat infectious diseases caused by gram-positive bacteria and mycoplasma in chickens. Such as staphylococcal disease, streptococcal disease, chronic respiratory disease and infectious rhinitis in chickens.

Calculated by this product. Mixed drink: 2.5g chicken per 1L water. It can be used continuously for 3~5 days.

 After oral administration, animals often have dose dependent gastrointestinal disorders, such as diarrhea.

(1) Chickens laying eggs for human consumption shall not be used during the laying period.
(2) This product should not be compatible with acidic substances.

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