Kev txhaj tshuaj Enrofloxacin

Enrofloxacin

Cov khoom no tsis muaj xim rau daj ntseg daj ntshiab kua.

Pharmacodynamic Enrofloxacin yog ib qho dav-spectrum bactericidal tshuaj tshwj xeeb uas siv rau cov tsiaj fluoroquinolone. Rau e. coli, salmonella, klebsiella, brucella, pasteurella, pleuropneumonia actinobacillus, erysipelas, bacillus proteus, clayey Mr Charest tus kab mob, suppurative corynebacterium, defeated ntshav pott's kab mob, staphylococcus aureus, tag nrho cov kab mob ntawm mycoplasma uginosa thiab streptococcus tsis muaj zog, tsis muaj zog ntawm cov kab mob anaerobic. Nws muaj qhov pom tseeb tom qab antibacterial nyhuv rau cov kab mob rhiab heev. Cov tshuaj tua kab mob ua haujlwm ntawm cov khoom no yog txhawm rau tiv thaiv cov kab mob DNA rotase, cuam tshuam nrog kev rov ua dua, kev hloov pauv thiab kho cov kab mob DNA rov ua dua, cov kab mob tsis tuaj yeem loj hlob thiab rov tsim dua qub thiab tuag.

Pharmacokinetics Cov tshuaj tau nqus sai thiab ua tiav los ntawm kev txhaj tshuaj intramuscular. Qhov bioavailability yog 91.9% hauv npua thiab 82% hauv nyuj. Nws yog dav faib nyob rau hauv cov tsiaj thiab tuaj yeem nkag mus rau cov ntaub so ntswg thiab cov kua dej hauv lub cev zoo. Tsuas yog cov kua dej cerebrospinal, qhov concentration ntawm cov tshuaj nyob rau hauv yuav luag tag nrho cov ntaub so ntswg yog siab dua li cov plasma. Lub luag haujlwm tseem ceeb hauv lub siab yog kev tshem tawm ntawm ethyl ntawm 7-piperazine nplhaib los tsim ciprofloxacin, tom qab ntawd oxidation thiab glucuronic acid khi. Feem ntau los ntawm lub raum (lub raum tubular secretion thiab glomerular filtration) tawm, 15% ~ 50% nyob rau hauv thawj daim ntawv los ntawm cov zis. Kev tshem tawm ib nrab-lub neej ntawm kev txhaj tshuaj intramuscular yog 5.9 teev hauv cov nyuj, 1.5 ~ 4.5 teev hauv yaj, thiab 4.6 teev hauv npua.

(1) Cov khoom no muaj cov nyhuv synergistic thaum ua ke nrog aminoglycosides lossis broad-spectrum penicillin.

(2) Ca2+, Mg2+, Fe3+, Al3+ thiab lwm yam hnyav hlau ions tuaj yeem chelate nrog cov khoom no, cuam tshuam rau kev nqus.

(3) Thaum ua ke nrog theophylline thiab caffeine, plasma protein khi tus nqi txo, thiab cov concentration ntawm theophylline thiab caffeine hauv cov ntshav yog txawv txav.

Txawm tias tshwm sim theophylline lom cov tsos mob.

(4) Cov khoom no muaj cov nyhuv inhibiting daim siab tshuaj enzymes, uas yuav txo tau cov clearance tus nqi ntawm cov tshuaj mas metabolized nyob rau hauv daim siab, thiab ua kom cov ntshav concentration ntawm cov tshuaj.

[Lub luag haujlwm thiab kev siv] Quinolones tshuaj tua kab mob. Nws yog siv rau cov kab mob kab mob thiab kab mob mycoplasma ntawm cov tsiaj nyeg thiab nqaij qaib.

Quinolone tshuaj tua kab mob. Nws yog siv rau cov kab mob kab mob thiab kab mob mycoplasma ntawm cov tsiaj nyeg thiab nqaij qaib.

Intramuscular txhaj: ib koob, 0.025ml ib 1kg lub cev hnyav rau nyuj, yaj thiab npua; dev, miv, luav 0.025-0.05 ml. Siv nws ib zaug lossis ob zaug ib hnub rau ob mus rau peb hnub.

(1) Cov pob txha mos degeneration tshwm sim hauv cov tsiaj me, cuam tshuam rau pob txha loj hlob thiab ua rau claudication thiab mob.

(2) Cov kev cuam tshuam ntawm lub plab zom mov muaj xws li ntuav, tsis qab los noj mov, raws plab, thiab lwm yam.

(3) Cov tshuaj tiv thaiv ntawm daim tawv nqaij muaj xws li erythema, pruritus, urticaria thiab photosensitive cov tshuaj tiv thaiv.

(4) Kev ua xua, ataxia thiab qaug dab peg muaj qee zaum pom hauv dev thiab miv.

(1) Nws muaj peev xwm excitatory nyhuv ntawm lub hauv paus system thiab tuaj yeem ua rau qaug dab peg. Nws yuav tsum tau siv nrog ceev faj hauv cov dev uas muaj mob vwm.

(2) Carnivores thiab cov tsiaj uas muaj lub raum tsis zoo siv nrog ceev faj, qee zaus tuaj yeem tso zis.

(3) Cov khoom no tsis haum rau cov dev ua ntej 8 lub lis piam.

(4) Cov tshuaj tiv thaiv kab mob ntawm cov khoom no nce ntxiv, yog li nws yuav tsum tsis txhob siv rau hauv cov tshuaj subtherapeutic ntev.