jakisoni wa Enrofloxacin

Enrofloxacin

Izi zimakhala zopanda mtundu mpaka zotumbululuka zamadzimadzi zowoneka bwino zachikasu.

Pharmacodynamic Enrofloxacin ndi yotakata sipekitiramu bactericidal mankhwala makamaka ntchito fluoroquinolone nyama. Za e. coli, salmonella, klebsiella, brucella, pasteurella, pleuropneumonia actinobacillus, erysipelas, bacillus proteus, clayey Mr Charest's bacteria, suppurative corynebacterium, ogonjetsa magazi pott's bacteria, staphylococcus aureus, mycoplasma, etc. ndi streptococcus ndi ofooka, ofooka mphamvu pa anaerobic mabakiteriya. Zili ndi zotsatira zoonekeratu za post-antibacterial pa mabakiteriya okhudzidwa. The antibacterial kanthu limagwirira wa mankhwala ndi ziletsa bakiteriya DNA atembenuza, kusokoneza kugawanika, transcript ndi kukonza bakiteriya DNA recombination, bakiteriya sangathe kukula ndi kubereka bwinobwino ndi kufa.

Pharmacokinetics Mankhwalawa adayamwa mwachangu komanso kwathunthu ndi jakisoni wamuscular. The bioavailability inali 91.9% mu nkhumba ndi 82% mu ng'ombe. Amagawidwa kwambiri mu nyama ndipo amatha kulowa bwino mu minofu ndi madzi amthupi. Kupatula cerebrospinal fluid, kuchuluka kwa mankhwala pafupifupi m'magulu onse ndikokwera kuposa m'madzi a m'magazi. Chachikulu cha chiwindi kagayidwe ndiko kuchotsa ethyl wa 7-piperazine mphete kupanga ciprofloxacin, kenako makutidwe ndi okosijeni ndi glucuronic asidi kumanga. Makamaka kudzera mu impso (impso tubular secretion ndi glomerular filtration) kutuluka, 15% ~ 50% mu mawonekedwe oyambirira a mkodzo. Kuthetsa theka la moyo wa jekeseni mu mnofu anali 5.9 maola ng'ombe mkaka, 1.5 ~ 4.5 maola nkhosa, ndi 4.6 maola nkhumba.

(1) Izi zimakhala ndi synergistic kwenikweni zikaphatikizidwa ndi aminoglycosides kapena ma penicillin ambiri.

(2) Ca2+, Mg2+, Fe3+, Al3+ ndi ayoni ena olemera achitsulo amatha chelate ndi mankhwalawa, zomwe zimakhudza kuyamwa.

(3) Akaphatikizidwa ndi theophylline ndi caffeine, kuchuluka kwa mapuloteni a plasma kumachepetsedwa, ndipo kuchuluka kwa theophylline ndi caffeine m'magazi kumawonjezeka modabwitsa.

Ngakhale kuoneka zizindikiro za poizoni theophylline.

(4) Izi mankhwala ndi zotsatira za inhibiting chiwindi michere mankhwala, amene angathe kuchepetsa chilolezo mlingo wa mankhwala zimapukusidwa mu chiwindi, ndi kuonjezera magazi ndende ya mankhwala.

[Ntchito ndi ntchito] Quinolones antibacterial mankhwala. Amagwiritsidwa ntchito pa matenda a bakiteriya ndi matenda a mycoplasma a ziweto ndi nkhuku.

Quinolones antibacterial mankhwala. Amagwiritsidwa ntchito pa matenda a bakiteriya ndi matenda a mycoplasma a ziweto ndi nkhuku.

Mu mnofu jekeseni: mlingo umodzi, 0.025ml pa 1kg thupi ng'ombe, nkhosa ndi nkhumba; Agalu, amphaka, akalulu 0.025-0.05 ml. Gwiritsani ntchito kamodzi kapena kawiri pa tsiku kwa masiku awiri kapena atatu.

(1) Kuwonongeka kwa cartilage kumachitika mwa nyama zazing'ono, zomwe zimakhudza kukula kwa mafupa ndikupangitsa kuti claudication ndi ululu.

(2) Zomwe zimachitika m'matumbo am'mimba zimaphatikizapo kusanza, kusowa kwa njala, kutsekula m'mimba, etc.

(3) Zomwe zimachitika pakhungu zimaphatikizapo erythema, pruritus, urticaria ndi mawonekedwe a photosensitive.

(4) Zotsatira zoyipa, ataxia ndi khunyu nthawi zina zimawonedwa mwa agalu ndi amphaka.

(1) Imakhala ndi mphamvu yosangalatsa pakatikati ndipo imatha kuyambitsa khunyu. Iyenera kugwiritsidwa ntchito mosamala agalu omwe ali ndi khunyu.

(2) Nyama zodya nyama ndi nyama zodwala aimpso ntchito mosamala, nthawi zina zimatha crystalline mkodzo.

(3) Izi sizoyenera agalu asanakwanitse milungu 8.

(4) Mankhwala osamva mankhwala a mankhwalawa akuwonjezeka, choncho sayenera kugwiritsidwa ntchito mu subtherapeutic mlingo kwa nthawi yaitali.