Umjovo we-Enrofloxacin

I-Enrofloxacin

Lo mkhiqizo awunambala uketshezi olucacile oluphuzi kuya kokuphuzi.

I-Pharmacodynamic Enrofloxacin isidakamizwa esibulala amagciwane esibanzi esisetshenziswa ngokukhethekile ezilwaneni ze-fluoroquinolone. Okwe-e. coli, i-salmonella, i-klebsiella, i-brucella, i-pasteurella, i-pleuropneumonia actinobacillus, i-erysipelas, i-bacillus proteus, i-clayey amagciwane kaMnu Charest, i-suppurative corynebacterium, i-blood pott's bacterium, i-staphylococcus aureus, i-mycoplasma, njll. futhi i-streptococcus ibuthakathaka, umphumela obuthakathaka kubhaktheriya ye-anaerobic. Inomphumela osobala we-post-antibacterial kuma-bacteria azwelayo. Isenzo se-antibacterial salo mkhiqizo ukuvimbela ukujikeleza kwe-DNA yebhaktheriya, ukuphazamisa ukuphindaphinda, ukulotshwa kanye nokulungiswa kokuhlanganiswa kabusha kwe-DNA yebhaktheriya, amagciwane awakwazi ukukhula nokuzalana ngokujwayelekile futhi afe.

I-Pharmacokinetics Umuthi wamuncwa ngokushesha nangokuphelele ngomjovo we-intramuscular. I-bioavailability yayingama-91.9% ezingulubeni kanye nama-82% ezinkomeni. Isatshalaliswa kabanzi ezilwaneni futhi ingangena kahle ezicutshini nasemanzini omzimba. Ngaphandle koketshezi lwe-cerebrospinal, ukugcwala kwezidakamizwa cishe kuzo zonke izicubu kungaphezulu kwalokho ku-plasma. Umetabolism oyinhloko we-hepatic ukususwa kwe-ethyl ye-7-piperazine ring ukukhiqiza i-ciprofloxacin, kulandelwa i-oxidation ne-glucuronic acid ebophayo. Ikakhulukazi ngezinso (i-renal tubular secretion kanye nokuhlunga kwe-glomerular) ukuphuma, 15% ~ 50% ngesimo sokuqala esivela emchameni. Ukuqedwa kwesigamu sempilo yomjovo we-intramuscular kwaba amahora angu-5.9 ezinkomeni zobisi, amahora angu-1.5 ~ 4.5 ezimvini, namahora angu-4.6 ezingulubeni.

(1) Lo mkhiqizo unomphumela we-synergistic uma uhlanganiswa nama-aminoglycosides noma i-penicillin ebanzi.

(2) I-Ca2+, i-Mg2+, i-Fe3+, i-Al3+ namanye ama-ion ensimbi angakwazi ukuxubha ngalo mkhiqizo, okuthinta ukumuncwa.

(3) Lapho kuhlanganiswa ne-theophylline ne-caffeine, izinga lokubopha amaprotheni e-plasma liyancishiswa, futhi ukugcwala kwe-theophylline ne-caffeine egazini kwenyuke ngendlela engavamile.

Ngisho nezimpawu ze-theophylline zibonakala.

(4) Lo mkhiqizo unomphumela wokuvimbela ama-enzyme ezidakamizwa zesibindi, anganciphisa izinga lokusulwa kwezidakamizwa ezigaywe kakhulu esibindini, futhi andise ukugcwala kwegazi kwezidakamizwa.

[Indima nokusetshenziswa] Imithi elwa namagciwane e-quinolones. Isetshenziselwa izifo ezibangelwa amagciwane kanye nezifo ze-mycoplasma yemfuyo nezinkukhu.

Izidakamizwa ezilwa namagciwane e-quinolones. Isetshenziselwa izifo ezibangelwa amagciwane kanye nezifo ze-mycoplasma yemfuyo nezinkukhu.

Umjovo we-Intramuscular: umthamo owodwa, 0.025ml ngesisindo somzimba esingu-1kg sezinkomo, izimvu nezingulube; Izinja, amakati, onogwaja 0.025-0.05 ml. Yisebenzise kanye noma kabili ngosuku izinsuku ezimbili kuya kwezintathu.

(1) Ukuwohloka kwe-cartilage kwenzeka ezilwaneni ezincane, okuthinta ukuthuthukiswa kwamathambo futhi kubangele i-claudication nobuhlungu.

(2) Ukusabela kwesistimu yokugaya ukudla kubandakanya ukuhlanza, ukulahlekelwa ukudla, isifo sohudo, njll.

(3) Ukusabela kwesikhumba kuhlanganisa i-erythema, pruritus, urticaria kanye nokusabela kwe-photosensitive.

(4) Ukungezwani komzimba, i-ataxia kanye nokuquleka kubonakala ngezikhathi ezithile ezinjeni nasemakati.

(1) Kunomphumela ovusa amadlingozi ohlelweni olumaphakathi futhi kungabangela ukuquleka kwesithuthwane. Kufanele isetshenziswe ngokuqapha ezinjeni ezinesifo sokuwa.

(2) Izilwane ezidla inyama nezilwane ezinokungasebenzi kahle kwezinso zisebenzisa ngokuqapha, ngezinye izikhathi zingagqamisa umchamo.

(3) Lo mkhiqizo awuzifanele izinja ngaphambi kwamasonto angu-8 ubudala.

(4) Izinhlobo zalo mkhiqizo ezimelana nezidakamizwa ziyanda, ngakho-ke akufanele zisetshenziswe kumthamo we-subtherapeutic isikhathi eside.