Jekiseni reEnrofloxacin

Enrofloxacin

Ichi chigadzirwa hachina ruvara kune yakachenuruka yero yakachena mvura.

Pharmacodynamic Enrofloxacin mushonga wakafara-spectrum bactericidal unonyanya kushandiswa fluoroquinolone mhuka. Nokuti e. coli, salmonella, klebsiella, brucella, pasteurella, pleuropneumonia actinobacillus, erysipelas, bacillus proteus, clayey Mr Charest's bacteria, suppurative corynebacterium, kukundwa ropa pott's bacteria, staphylococcus aureus, mycoplasma, nezvimwe zvose zvine basa rakanaka,rugmona chlamydia. uye streptococcus haina simba, isina simba mhedzisiro pane anaerobic mabhakitiriya. Iyo ine pachena post-antibacterial mhedzisiro pahutachiona hwehutachiona. Iyo inorwisa mabhakitiriya chiito chechigadzirwa ichi kuvharidzira kutenderera kwebhakitiriya, kukanganisa kudzokorodza, kunyora uye kugadzirisa kweiyo bhakitiriya DNA recombination, bhakitiriya haigone kukura uye kubereka zvakajairwa uye kufa.

Pharmacokinetics Mushonga wacho wakatorwa nekukurumidza uye zvachose nejekiseni re intramuscular. Iyo bioavailability yaive 91.9% munguruve uye 82% mumhou. Inoparadzirwa zvakanyanya mumhuka uye inogona kupinda munyama uye mvura yemuviri zvakanaka. Kunze kwecerebrospinal fluid, kuwanda kwezvinodhaka munenge matishu ese akakwira kupfuura ari muplasma. Iyo huru yehepatic metabolism ndeye kubviswa kwe ethyl ye7-piperazine ring kuti ibudise ciprofloxacin, inoteverwa neoxidation uye glucuronic acid inosunga. Kunyanya kuburikidza neitsvo (renal tubular secretion uye glomerular filtration) kubuda, 15% ~ 50% muchimiro chepakutanga kubva muweti. Kubviswa kwehafu yehupenyu hwejekiseni ye intramuscular yaiva maawa 5.9 mumombe dzemukaka, 1.5 ~ 4.5 maawa mumakwai, uye maawa 4.6 munguruve.

(1) Ichi chigadzirwa chine synergistic mhedzisiro kana chasanganiswa neaminoglycosides kana yakakura-spectrum penicillin.

(2) Ca2+, Mg2+, Fe3+, Al3+ uye mamwe maion anorema esimbi anogona chelate nechigadzirwa ichi, zvichikanganisa kunyura.

(3) Kana yakabatanidzwa ne theophylline uye caffeine, iyo plasma protein binding rate inoderedzwa, uye kusanganiswa kwetheophylline uye caffeine muropa kunowedzera zvisiri izvo.

Kunyange kuonekwa theophylline chepfu zviratidzo.

(4) Ichi chigadzirwa chine mhedzisiro yekuvharisa chiropa chemishonga enzymes, iyo inogona kuderedza chiyero chekuregererwa kwemishonga inonyanya kushandiswa muchiropa, uye kuwedzera kuwanda kweropa remishonga.

[Basa uye kushandisa] Quinolones antibacterial mishonga. Inoshandiswa kune zvirwere zvebhakitiriya uye mycoplasma zvirwere zvezvipfuwo uye huku.

Quinolones antibacterial drugs. Inoshandiswa kune zvirwere zvebhakitiriya uye mycoplasma zvirwere zvezvipfuwo uye huku.

Intramuscular jekiseni: imwe dose, 0.025ml pa 1kg muviri uremu mombe, makwai nenguruve; Imbwa, katsi, tsuro 0.025-0.05 ml. Shandisa kamwe kana kaviri pazuva kwemazuva maviri kusvika matatu.

(1) Cartilage degeneration inoitika mumhuka diki, inokanganisa kukura kwemapfupa uye kukonzera claudication uye kurwadziwa.

(2) Mabatiro anoita digestive system anosanganisira kurutsa, kurasikirwa nechido, manyoka, nezvimwe.

(3) Kuita kweganda kunosanganisira erythema, pruritus, urticaria uye photosensitive reaction.

(4) Allergic reactions, ataxia uye pfari zvinomboonekwa mumbwa nekatsi.

(1) Iyo ine inogona kufadza mhedzisiro pane yepakati system uye inogona kukonzera pfari pfari. Inofanira kushandiswa nekuchenjerera mumbwa dzine pfari.

(2) Mhuka dzinodya nyama uye mhuka dzisina kushanda zvakanaka renal dzinoshandisa nekuchenjerera, dzimwe nguva dzinogona kuchenesa weti.

(3) Ichi chigadzirwa hachina kukodzera imbwa pamberi pemavhiki masere ezera.

(4) Mishonga inopesana nemishonga yechigadzirwa ichi iri kuwedzera, saka haifanirwe kushandiswa mune subtherapeutic dose kwenguva yakareba.