Isitofu se-Enrofloxacin

Enrofloxacin

Le mveliso ayinambala ukuya kolulwelo oluluthubi olucacileyo.

I-Pharmacodynamic Enrofloxacin lichiza elibanzi le-bactericidal elisetyenziswa ngokukodwa kwizilwanyana ze-fluoroquinolone. Kuba e. coli, salmonella, klebsiella, brucella, pasteurella, pleuropneumonia actinobacillus, erysipelas, bacillus proteus, clayey ibhaktiriya kaMnu Charest, suppurative corynebacterium, ukoyiswa kwebhaktiriya ye-pott yegazi, i-staphylococcus aureus, i-mycoplasma, i-mycoplasma, njl njl. kwaye i-streptococcus ibuthathaka, isiphumo esibuthathaka kwibhaktheriya ye-anaerobic. Inesiphumo esicacileyo se-post-antibacterial kwiibhaktheriya ezibuthathaka. Indlela yokusebenza ye-antibacterial yale mveliso kukuthintela ukujikeleza kwe-DNA yebhaktiriya, ukuphazamisa ukuphindaphinda, ukubhalwa kunye nokulungiswa kwe-bacterial DNA recombination, ibhaktheriya ayikwazi ukukhula kwaye ivelise ngokuqhelekileyo kwaye ife.

I-Pharmacokinetics Ichiza lifunxwe ngokukhawuleza nangokupheleleyo ngenaliti ye-intramuscular. I-bioavailability yaba yi-91.9% kwiihagu kunye ne-82% kwiinkomo. Isasazwa ngokubanzi kwizilwanyana kwaye inokungena kwizicubu kunye nolwelo lomzimba kakuhle. Ngaphandle kwe-cerebrospinal fluid, ukuxinwa kweziyobisi phantse kuzo zonke izihlunu kuphezulu kunoko kwiplasma. I-metabolism ephambili ye-hepatic kukususwa kwe-ethyl ye-7-piperazine ring ukuvelisa i-ciprofloxacin, ilandelwa yi-oxidation kunye ne-glucuronic acid yokubopha. Ikakhulu ngezintso (i-renal tubular secretion kunye ne-glomerular filtration) ukukhutshwa, i-15% ~ 50% kwifom yokuqala evela kumchamo. Ukupheliswa kwesiqingatha sobomi benaliti ye-intramuscular yayiziiyure ezi-5.9 kwiinkomo zobisi, i-1.5 ~ 4.5 iiyure kwiigusha, kunye neeyure ezi-4.6 kwiihagu.

(1) Le mveliso inefuthe le-synergistic xa idibene ne-aminoglycosides okanye i-penicillin ebanzi.

(2) I-Ca2 +, i-Mg2 +, i-Fe3 +, i-Al3 + kunye nezinye i-ion zetsimbi ezinobunzima ziyakwazi ukutshisa kunye nale mveliso, echaphazela ukufunxa.

(3) Xa idityaniswe ne-theophylline kunye ne-caffeine, i-plasma protein binding rate iyancitshiswa, kwaye ukuxinwa kwe-theophylline kunye ne-caffeine egazini kwanda ngokungaqhelekanga.

Nokuba zibonakala iimpawu zetyhefu ye-theophylline.

(4) Le mveliso inefuthe lokuthintela i-enzyme yeziyobisi zesibindi, ezinokunciphisa izinga lokucocwa kweziyobisi ezixutywe kakhulu esibindini, kwaye zandise ukuxinwa kwegazi kweziyobisi.

[Indima kunye nokusetyenziswa] Iiquinolones antibacterial amayeza. Isetyenziselwa izifo zebhaktheriya kunye nosulelo lwe-mycoplasma yemfuyo kunye neenkukhu.

Iiquinolones antibacterial drugs. Isetyenziselwa izifo zebhaktheriya kunye nosulelo lwe-mycoplasma yemfuyo kunye neenkukhu.

Inaliti ye-Intramuscular: idosi enye, i-0.025ml nge-1kg yobunzima bomzimba weenkomo, iigusha kunye neehagu; Izinja, iikati, onogwaja 0.025-0.05 ml. Yisebenzise kanye okanye kabini ngosuku iintsuku ezimbini ukuya kwezintathu.

(1) Ukutshatyalaliswa kwe-Cartilage kwenzeka kwizilwanyana ezincinci, ezichaphazela ukuphuhliswa kwamathambo kunye nokubangela i-claudication kunye nentlungu.

(2) Iimpendulo zenkqubo yokugaya ziquka ukuhlanza, ukulahlekelwa ngumdla, isifo sohudo, njl.

(3) Ukuphendula kwesikhumba kubandakanya i-erythema, pruritus, urticaria kunye ne-photosensitive reaction.

(4) Ukuxhatshazwa kwe-allergic, i-ataxia kunye nokuxhuzula kubonakala ngezinye izihlandlo kwizinja kunye neekati.

(1) Unempembelelo enokubakho kwi-excitatory system kwaye inokubangela ukuxhuzula. Kufuneka isetyenziswe ngononophelo kwizinja ezinesifo sokuwa.

(2) Izilwanyana ezidla inyama kunye nezilwanyana ezinokungasebenzi kakuhle kwezintso zisetyenziswa ngononophelo, ngamanye amaxesha zinokuqaqambisa umchamo.

(3) Le mveliso ayifanelekanga izinja ngaphambi kweeveki ezi-8 ubudala.

(4) Iintlobo ze-resistant-resistant zale mveliso ziyanda, ngoko ke akufanele zisetyenziswe kwidosi ye-subtherapeutic ixesha elide.